DegronMD

Uniprot ID: O95886

Source protein: Disks large-associated protein 3

Source gene: DLGAP3

Class: DEG_SCF_TRCP1_1

Location: 784:789

E3 ligase: BTRC

DEGRON score: 0.9891

ASA_SCORE: 86.5667

COIL: 0.927

CONS_SCORE: 0.6892

DSS_SCORE: 0.5816

HELIX: 0.0423

FCONS_SCORE: 1.1258

RIG_SCORE: 0.592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D784E	TCGA-22-5471	LUSC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.6758
p.D784E	DO27500	LUSC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.6758
p.P783L	TCGA-56-6546	LUSC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.3056
p.P783L	DO26542	LUSC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.3056
p.E776Q	TCGA-A7-A5ZV	BRCA	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.1111
p.E776Q	DO44115	BRCA	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.1111
p.R787H	TCGA-AP-A1DK	UCEC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.7133
p.R787H	DO234437	ESAD	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.7133
p.R787H	DO233156	GACA	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.7133
p.R787H	DO42033	UCEC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.7133
p.G795C	TCGA-D3-A3C8	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.1667
p.G795C	DO47636	SKCM	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.1667
p.S789F	TCGA-EB-A3Y6	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.7982
p.S789F	DO38081	SKCM	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.7982
p.P792L	TCGA-EE-A2MC	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.25
p.P792L	TCGA-IH-A3EA	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.25
p.P792L	DO37667	SKCM	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.25
p.P792L	DO37559	SKCM	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.25
p.G795S	TCGA-EY-A549	UCEC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	0.1667
p.G795S	DO48174	UCEC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.1667
p.R793H	DO50454	ESAD	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.R793H	SIDM02021	Esophageal Carcinoma	GDSC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.R780H	DO234273	ESAD	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.P792Q	DO229026	LICA	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.25
p.R793S	DO229035	LICA	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.R793C	DO231628	LINC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.R780C	DO229253	THCA	ICGC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.R780C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGRAS	DEG_SCF_TRCP1_1	0.2222
p.R780C	ACH-000995	Leukemia	CCLE	DSGRAS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95886	Disks large-associated protein 3	DEG_SCF_TRCP1_1	784:789	DSGRAS	BTRC	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRAS

Degron related mutations and impact score

Drug responses associated with DLGAP3 mutations

All proteins holding degron of DSGRAS