DegronMD

Uniprot ID: O95886

Source protein: Disks large-associated protein 3

Source gene: DLGAP3

Class: DEG_APCC_DBOX_1

Location: 50:58

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9309

ASA_SCORE: 71.2556

COIL: 0.8662

CONS_SCORE: 0.3019

DSS_SCORE: 0.4968

HELIX: 0.0493

FCONS_SCORE: 0.7668

RIG_SCORE: 0.659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P50L	TCGA-55-8091	LUAD	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	0.6471
p.P50L	DO45334	LUAD	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.6471
p.E44K	TCGA-EE-A2GP	SKCM	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.E44K	TCGA-EO-A3B0	UCEC	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.E44K	DO37422	SKCM	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.E44K	DO219773	UCEC	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.R51K	TCGA-EE-A2MS	SKCM	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	0.7237
p.R51K	DO37567	SKCM	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.7237
p.P59S	TCGA-FW-A3R5	SKCM	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	0.3056
p.P59S	DO37406	SKCM	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.3056
p.S64R	DO228974	LICA	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.S64R	DO229018	LICA	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.A52D	DO229015	LICA	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.6682
p.S64I	DO27484	LUSC	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.S64N	SIDM02059	Colorectal Carcinoma	GDSC	PRAGLGHIS	DEG_APCC_DBOX_1	0.1667
p.I57L	SIDM00845	Burkitt's Lymphoma	GDSC	PRAGLGHIS	DEG_APCC_DBOX_1	0.6063
p.P62A	SIDM00878	Breast Carcinoma	GDSC	PRAGLGHIS	DEG_APCC_DBOX_1	0.2222
p.P62A	ACH-000930	Breast Cancer	CCLE	PRAGLGHIS	DEG_APCC_DBOX_1	0.2222
p.P62A	HCC1569	breast	COSMIC	PRAGLGHIS	DEG_APCC_DBOX_1	0.2222
p.S42C	ACH-000800	Lung Cancer	CCLE	PRAGLGHIS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95886	Disks large-associated protein 3	DEG_APCC_DBOX_1	50:58	PRAGLGHIS	APC,CDC20,FZR1	0.9309	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons