DegronMD

Uniprot ID: O95886

Source protein: Disks large-associated protein 3

Source gene: DLGAP3

Class: DEG_SPOP_SBC_1

Location: 558:562

E3 ligase: SPOP

DEGRON score: 0.9926

ASA_SCORE: 75.98

COIL: 0.8164

CONS_SCORE: 0.6101

DSS_SCORE: 0.6896

HELIX: 0.0668

FCONS_SCORE: 1.2153

RIG_SCORE: 0.6078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A565T	SIDM01307	Colorectal Carcinoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.25
p.H566Q	SIDM01071	Small Cell Lung Carcinoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.2222
p.H566Q	ACH-000515	Lung Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	559:563	AQSST	SPOP	0.9964	More...
O95886	Disks large-associated protein 3	DEG_SPOP_SBC_1	558:562	AQSST	SPOP	0.9926	More...
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SPOP_SBC_1	284:288	AQSST	SPOP	0.9813	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SPOP_SBC_1	120:124	AQSST	SPOP	0.6813	More...
Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	DEG_SPOP_SBC_1	344:348	AQSST	SPOP	0.929	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	630:634	AQSST	SPOP	0.992	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	130:134	AQSST	SPOP	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons