DegronMD - Q9BZB8(CPEB1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P110H	TCGA-23-1123	OV	TCGA	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.A120D	TCGA-37-4130	LUSC	TCGA	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7793
p.P272H	TCGA-55-7913	LUAD	TCGA	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.0556
p.A239D	TCGA-AA-3984	COAD	TCGA	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.2222
p.L131F	TCGA-AN-A046	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.L240F	TCGA-AP-A1DM	UCEC	TCGA	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.25
p.W111C	TCGA-AR-A0U4	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.S258F	TCGA-AX-A2HC	UCEC	TCGA	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.6871
p.S249R	TCGA-C8-A138	BRCA	TCGA	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.3056
p.S249R	TCGA-C8-A138	BRCA	TCGA	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.1944
p.A250T	TCGA-EO-A22R	UCEC	TCGA	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.2778
p.A250T	TCGA-EO-A22R	UCEC	TCGA	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.2222
p.L240I	TCGA-EO-A3B0	UCEC	TCGA	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.25
p.L240I	DO8264	COAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.25
p.R253T	TCGA-IR-A3LK	CESC	TCGA	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1944
p.R253T	TCGA-IR-A3LK	CESC	TCGA	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.3056
p.V253G	DO1285	BRCA	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1944
p.V253G	DO1285	BRCA	ICGC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.3056
p.F259V	DO8842	COAD	ICGC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.7068
p.P244S	DO8730	COAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation altering degron motif	0.6752
p.R131C	DO222798	COCA	ICGC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.S235F	DO222884	COCA	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1111
p.G260S	DO23292	LINC	ICGC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.6993
p.D121Y	DO23678	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7325
p.D121H	DO23602	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7688
p.W245R	DO230976	LUSC	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation altering degron motif	0.8634
p.W245R	DO224626	LUSC	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation altering degron motif	0.8634
p.G271S	DO47331	SKCM	ICGC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.0833
p.D246Y	DO42608	UCEC	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation altering degron motif	0.7325
p.K237N	DO42825	UCEC	ICGC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1667
p.A242V	SIDM01951	Colorectal Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.3056
p.A242V	SIDM00999	Bladder Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.3056
p.A242V	639-V	urinary tract	COSMIC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.3056
p.G256E	SIDM00504	Glioma	GDSC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.6087
p.G256E	MOG-G-UVW	central nervous system	COSMIC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.6087
p.S122R	SIDM00081	Melanoma	GDSC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7427
p.S122R	SIDM01567	Hodgkin's Lymphoma	GDSC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7427
p.D234N	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.0833
p.G255R	ACH-000196	Breast Cancer	CCLE	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.7568
p.G255R	HCC1599	breast	COSMIC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.7568
p.D121G	ACH-000786	Lymphoma	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7198
p.D121G	ACH-000992	Head and Neck Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7198
p.D121G	ACH-001067	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7198
p.D121G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7198
p.D121G	Daudi	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7198
p.S113P	ACH-000786	Lymphoma	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.S113P	ACH-000992	Head and Neck Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.S113P	ACH-001067	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.S113P	Daudi	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.G133S	ACH-000823	Esophageal Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.G133S	KYSE-140	oesophagus	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.R233H	ACH-000952	Prostate Cancer	CCLE	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.0556
p.A269V	ACH-000973	Bladder Cancer	CCLE	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.1389
p.A269V	639-V	urinary tract	COSMIC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation rewiring degron network	0.1389
p.D110G	COR-L95	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.T133I	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.A245V	639-V	urinary tract	COSMIC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation altering degron motif	0.6936
p.D245G	COR-L95	lung	COSMIC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation altering degron motif	0.7198
p.I114T	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1667
p.H119N	HT-115	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.P234H	LN-18	central nervous system	COSMIC	VTPSPT	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.0833
p.G259E	MOG-G-UVW	central nervous system	COSMIC	WPGASVWPS	DEG_SIAH_1	254:262	Mutation altering degron motif	0.7199

Kaplan plot for CPEB1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPEB1

UniProt ID: Q9BZB8

Entrez ID: 64506

Protein name: Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CPEB1 in