DegronMD

Uniprot ID: Q9BZB8

Source protein: Cytoplasmic polyadenylation element-binding protein 1

Source gene: CPEB1

Class: DEG_SCF_FBW7_1

Location: 243:248

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 78.2

COIL: 0.9067

CONS_SCORE: 0.3482

DSS_SCORE: 0.5475

HELIX: 0.0703

FCONS_SCORE: 1.1208

RIG_SCORE: 0.6791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A239D	TCGA-AA-3984	COAD	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.2222
p.L240F	TCGA-AP-A1DM	UCEC	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.25
p.S249R	TCGA-C8-A138	BRCA	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.3056
p.A250T	TCGA-EO-A22R	UCEC	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.2778
p.L240I	TCGA-EO-A3B0	UCEC	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.25
p.L240I	DO8264	COAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.25
p.R253T	TCGA-IR-A3LK	CESC	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.1944
p.V253G	DO1285	BRCA	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.1944
p.P244S	DO8730	COAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.6752
p.S235F	DO222884	COCA	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.1111
p.W245R	DO230976	LUSC	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.8634
p.W245R	DO224626	LUSC	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.8634
p.D246Y	DO42608	UCEC	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.7325
p.K237N	DO42825	UCEC	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.1667
p.A242V	SIDM01951	Colorectal Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	0.3056
p.A242V	SIDM00999	Bladder Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	0.3056
p.A242V	639-V	urinary_tract	COSMIC	VTPSPT	DEG_SCF_FBW7_1	0.3056
p.D234N	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	0.0833
p.R233H	ACH-000952	Prostate Cancer	CCLE	VTPSPT	DEG_SCF_FBW7_1	0.0556
p.A245V	639-V	urinary_tract	COSMIC	VTPSPT	DEG_SCF_FBW7_1	0.6936
p.D245G	COR-L95	lung	COSMIC	VTPSPT	DEG_SCF_FBW7_1	0.7198
p.P234H	LN-18	central_nervous_system	COSMIC	VTPSPT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_FBW7_1	338:343	VTPSPT	FBXW7	0.9883	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SCF_FBW7_1	243:248	VTPSPT	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons