DegronMD

Uniprot ID: Q92870

Source protein: Amyloid beta precursor protein binding family B member 2

Source gene: APBB2

Class: DEG_SCF_FBW7_1

Location: 338:343

E3 ligase: FBXW7

DEGRON score: 0.9883

ASA_SCORE: 86.2667

COIL: 0.953

CONS_SCORE: 0.4852

DSS_SCORE: 0.7076

HELIX: 0.011

FCONS_SCORE: 1.192

RIG_SCORE: 0.58

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V339I	TCGA-85-8288	LUSC	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.7076
p.V339I	DO26963	LUSC	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.7076
p.T340M	TCGA-AA-3811	COAD	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.7423
p.T340M	DO7962	COAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.7423
p.S342F	TCGA-D3-A8GB	SKCM	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.7982
p.S342F	DO50280	SKCM	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.7982
p.S335P	TCGA-D7-A4YY	STAD	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.25
p.S335P	DO47733	STAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.25
p.S335L	TCGA-FW-A3R5	SKCM	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.25
p.P343L	TCGA-IH-A3EA	SKCM	TCGA	VTPSPT	DEG_SCF_FBW7_1	0.7582
p.P343L	DO37667	SKCM	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.7582
p.S334L	DO37406	SKCM	ICGC	VTPSPT	DEG_SCF_FBW7_1	0.6667
p.R332S	SIDM01129	Small Cell Lung Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	0.6111
p.R332S	NCI-H524	lung	COSMIC	VTPSPT	DEG_SCF_FBW7_1	0.6111
p.R331S	NCI-H524	lung	COSMIC	VTPSPT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_FBW7_1	338:343	VTPSPT	FBXW7	0.9883	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SCF_FBW7_1	243:248	VTPSPT	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons