DegronMD - Q92870(APBB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E586K	TCGA-73-4658	LUAD	TCGA	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation rewiring degron network	0.3056
p.V339I	TCGA-85-8288	LUSC	TCGA	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7076
p.V339I	DO26963	LUSC	ICGC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7076
p.N28D	TCGA-A5-A0G2	UCEC	TCGA	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2222
p.N28D	DO41235	UCEC	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2222
p.P581L	TCGA-A5-A0GH	UCEC	TCGA	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation altering degron motif	0.7582
p.T340M	TCGA-AA-3811	COAD	TCGA	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7423
p.T340M	TCGA-AA-3811	COAD	TCGA	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7423
p.T340M	DO7962	COAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7423
p.T340M	DO7962	COAD	ICGC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7423
p.P754L	TCGA-AD-6964	COAD	TCGA	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1111
p.R753C	TCGA-AP-A059	UCEC	TCGA	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1389
p.V593M	TCGA-BR-4256	STAD	TCGA	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation rewiring degron network	0.1111
p.F17C	TCGA-BS-A0UF	UCEC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.2222
p.F17C	DO41488	UCEC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.2222
p.P345T	TCGA-D3-A2J6	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7031
p.P345T	DO37901	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7031
p.S342F	TCGA-D3-A8GB	SKCM	TCGA	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7982
p.S342F	TCGA-D3-A8GB	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7982
p.S342F	DO50280	SKCM	ICGC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7982
p.S342F	DO50280	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7982
p.S335P	TCGA-D7-A4YY	STAD	TCGA	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation rewiring degron network	0.25
p.S335P	TCGA-D7-A4YY	STAD	TCGA	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation rewiring degron network	0.1944
p.S335P	DO47733	STAD	ICGC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation rewiring degron network	0.25
p.S335P	DO47733	STAD	ICGC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation rewiring degron network	0.1944
p.P36S	TCGA-EB-A4XL	SKCM	TCGA	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.5641
p.P36S	DO47401	SKCM	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.5641
p.P36T	TCGA-FU-A23L	CESC	TCGA	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.5919
p.P36T	DO6278	CESC	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.5919
p.S335L	TCGA-FW-A3R5	SKCM	TCGA	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation rewiring degron network	0.25
p.S335L	TCGA-FW-A3R5	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation rewiring degron network	0.1944
p.P343L	TCGA-IH-A3EA	SKCM	TCGA	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7582
p.P343L	TCGA-IH-A3EA	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7582
p.P343L	DO37667	SKCM	ICGC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation altering degron motif	0.7582
p.P343L	DO37667	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation altering degron motif	0.7582
p.L572F	TCGA-WE-A8ZO	SKCM	TCGA	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation rewiring degron network	0.1111
p.P732L	DO8360	COAD	ICGC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1667
p.P582L	DO234268	ESAD	ICGC	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation altering degron motif	0.7582
p.A15T	DO223071	ESCA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.2778
p.A15V	DO233908	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.2778
p.V44L	DO228934	LICA	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1667
p.L48M	DO229041	LICA	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0556
p.S14P	DO51420	PRAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.3056
p.S334L	DO37406	SKCM	ICGC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation blocking phosphorylation signal	0.6667
p.S334L	DO37406	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation blocking phosphorylation signal	0.6111
p.G48A	DO50301	SKCM	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0556
p.L23F	DO51286	SKCM	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0833
p.L23F	DO51286	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.0556
p.V44M	DO38743	STAD	ICGC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1667
p.P737S	DO40884	UCEC	ICGC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.3056
p.T13A	SIDM02026	Colorectal Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation altering degron motif	0.7139
p.Q751H	SIDM00664	Pancreatic Carcinoma	GDSC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.3056
p.Q751H	ACH-000178	Pancreatic Cancer	CCLE	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.3056
p.Q751H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.3056
p.R332S	SIDM01129	Small Cell Lung Carcinoma	GDSC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation blocking ubiquitination signal	0.6111
p.R332S	SIDM01129	Small Cell Lung Carcinoma	GDSC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation blocking ubiquitination signal	0.5556
p.R332S	NCI-H524	lung	COSMIC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation blocking ubiquitination signal	0.6111
p.R332S	NCI-H524	lung	COSMIC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation blocking ubiquitination signal	0.5556
p.S744F	SIDM00140	Melanoma	GDSC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7982
p.S744F	ACH-000968	Skin Cancer	CCLE	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7982
p.S744F	COLO-792	skin	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7982
p.Q594R	SIDM01439	Hepatocellular Carcinoma	GDSC	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation rewiring degron network	0.0833
p.Q594R	SIDM01378	Ovarian Carcinoma	GDSC	PTPKTE	DEG_SCF_FBW7_2	580:585	Mutation rewiring degron network	0.0833
p.N30S	SIDM01580	Melanoma	GDSC	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2778
p.N30S	ACH-000240	Non-Cancerous	CCLE	PATPPNT	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2778
p.D12G	SIDM01519	Head and Neck Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation altering degron motif	0.6087
p.N737K	ACH-001282	Bone Cancer	CCLE	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.3056
p.A7V	OVISE	ovary	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	8:13	Mutation rewiring degron network	0.3056
p.D357E	ASH-3	thyroid	COSMIC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation rewiring degron network	0.0556
p.Q750H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222
p.S743F	COLO-792	skin	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7982
p.Q728H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.0556
p.R331S	NCI-H524	lung	COSMIC	VTPSPT	DEG_SCF_FBW7_1	338:343	Mutation rewiring degron network	0.1389
p.R331S	NCI-H524	lung	COSMIC	PSPTPENE	DEG_SCF_FBW7_2	340:347	Mutation rewiring degron network	0.0833
p.Q729H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APBB2

UniProt ID: Q92870

Entrez ID: 323

Protein name: Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for APBB2 in