DegronMD

Uniprot ID: Q92870

Source protein: Amyloid beta precursor protein binding family B member 2

Source gene: APBB2

Class: DEG_SCF_TRCP1_1

Location: 8:13

E3 ligase: BTRC

DEGRON score: 0.924

ASA_SCORE: 77.8167

COIL: 0.8045

CONS_SCORE: 0.3244

DSS_SCORE: 0.4123

HELIX: 0.1593

FCONS_SCORE: 0.8665

RIG_SCORE: 0.749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F17C	TCGA-BS-A0UF	UCEC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.2222
p.F17C	DO41488	UCEC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.2222
p.A15T	DO223071	ESCA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.A15V	DO233908	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.S14P	DO51420	PRAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.3056
p.L23F	DO51286	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.0556
p.T13A	SIDM02026	Colorectal Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.7139
p.D12G	SIDM01519	Head and Neck Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.6087
p.A7V	OVISE	ovary	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND56	Protein LSM14 homolog A	DEG_SCF_TRCP1_1	339:344	DSGVDT	BTRC	0.9941	More...
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_TRCP1_1	8:13	DSGVDT	BTRC	0.924	More...
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	DEG_SCF_TRCP1_1	622:627	DSGVDT	BTRC	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons