DegronMD - Q9UQ26(RIMS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A17D	TCGA-05-4382	LUAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.A17D	DO24900	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.R977Q	TCGA-06-0173	GBM	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	TCGA-12-1089	GBM	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	TCGA-CV-5440	HNSC	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	TCGA-FG-A87Q	LGG	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	DO12346	GBM	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	DO10886	GBM	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	DO14186	HNSC	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977Q	DO51830	LGG	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.G982E	TCGA-15-0742	GBM	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2222
p.G982E	TCGA-EY-A1GQ	UCEC	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2222
p.G982E	DO13623	GBM	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2222
p.G982E	DO43090	UCEC	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2222
p.R387M	TCGA-17-Z028	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.8632
p.R987L	TCGA-17-Z042	LUAD	TCGA	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8428
p.R987L	DO227564	PACA	ICGC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8428
p.D380Y	TCGA-17-Z056	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.D380Y	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.D380Y	NCI-H2110	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.G953W	TCGA-33-4532	LUSC	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7825
p.G953W	TCGA-A5-A0G2	UCEC	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7825
p.G953W	DO26626	LUSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7825
p.G953W	DO41235	UCEC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7825
p.M388L	TCGA-37-4130	LUSC	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.711
p.M388L	DO26490	LUSC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.711
p.P955H	TCGA-43-5668	LUSC	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7694
p.P955H	TCGA-55-8620	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7694
p.P955H	DO228609	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7694
p.P955H	DO24547	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7694
p.P955H	DO26608	LUSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7694
p.G991E	TCGA-49-6767	LUAD	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.25
p.G991E	DO23586	LUAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.25
p.G962R	TCGA-50-6590	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1389
p.G962R	DO24692	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1389
p.S627R	TCGA-55-1592	LUAD	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7427
p.S627R	DO234414	ESAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7427
p.S627R	DO233679	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7427
p.S627R	DO23556	LUAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7427
p.R965I	TCGA-55-8616	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation substituting flanking lysine	0.1667
p.R965I	TCGA-HU-8604	STAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation substituting flanking lysine	0.1667
p.R965I	DO23566	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation substituting flanking lysine	0.1667
p.R965I	DO47907	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation substituting flanking lysine	0.1667
p.P955T	TCGA-55-8620	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7031
p.P955T	DO24547	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7031
p.R8L	TCGA-56-7822	LUSC	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.8428
p.R8L	DO26638	LUSC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.8428
p.R471P	TCGA-64-5781	LUAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.3056
p.R471P	DO23740	LUAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.3056
p.Y993C	TCGA-64-5781	LUAD	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1944
p.Y993C	DO23740	LUAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1944
p.R387S	TCGA-69-7979	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.7427
p.R387S	DO23874	LUAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.7427
p.H459Y	TCGA-73-A9RS	LUAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1944
p.H459Y	DO51193	LUAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1944
p.S392L	TCGA-75-5126	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.S392L	DO23711	LUAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.V466L	TCGA-85-8355	LUSC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6765
p.V466L	DO233091	GACA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6765
p.V466L	DO45488	LUSC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6765
p.E475K	TCGA-90-A4ED	LUSC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1944
p.E475K	DO45482	LUSC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1944
p.I961M	TCGA-91-6836	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1667
p.I961M	DO23854	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1667
p.P955S	TCGA-99-8028	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.6752
p.P955S	DO23561	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.6752
p.R998Q	TCGA-A8-A08R	BRCA	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0556
p.R998Q	TCGA-AX-A0J0	UCEC	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0556
p.R998Q	TCGA-B5-A11J	UCEC	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0556
p.R998Q	DO1255	BRCA	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0556
p.R998Q	DO43698	UCEC	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0556
p.R998Q	DO41133	UCEC	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0556
p.R977W	TCGA-AA-3949	COAD	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.R977W	DO7798	COAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.E980K	TCGA-AD-6895	COAD	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1667
p.E980K	TCGA-D3-A8GP	SKCM	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1667
p.E980K	DO8938	COAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1667
p.E980K	DO51244	SKCM	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1667
p.S613L	TCGA-AG-3583	READ	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0833
p.S613L	DO36787	READ	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0833
p.R984Q	TCGA-AG-A002	READ	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2778
p.R984Q	TCGA-BR-8361	STAD	TCGA	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2778
p.R984Q	DO48032	STAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2778
p.S463G	TCGA-AP-A0LI	UCEC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation blocking phosphorylation signal	0.75
p.S463G	DO43658	UCEC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation blocking phosphorylation signal	0.75
p.S613T	TCGA-AP-A1DV	UCEC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0833
p.S613T	DO43186	UCEC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0833
p.P24L	TCGA-AU-3779	COAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0833
p.P24L	DO8626	COAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0833
p.R987C	TCGA-AX-A1CE	UCEC	TCGA	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8301
p.R987C	DO42280	UCEC	ICGC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8301
p.S463R	TCGA-B5-A3FA	UCEC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation blocking phosphorylation signal	0.75
p.S463R	DO52402	UCEC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation blocking phosphorylation signal	0.75
p.C617F	TCGA-BB-A5HY	HNSC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1944
p.C617F	DO218979	HNSC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1944
p.R987H	TCGA-BR-4368	STAD	TCGA	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8244
p.R987H	TCGA-D5-6928	COAD	TCGA	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8244
p.R987H	DO7776	COAD	ICGC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8244
p.R987H	DO38715	STAD	ICGC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.8244
p.R455Q	TCGA-BR-6452	STAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.R455Q	TCGA-VQ-A91K	STAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.R455Q	DO38404	STAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.R455Q	DO51785	STAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.R395I	TCGA-BS-A0TC	UCEC	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.R395I	DO42400	UCEC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.R395I	SIDM01156	Small Cell Lung Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.R395I	SW1271	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.H956D	TCGA-BT-A0YX	BLCA	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.75
p.H956D	DO516	BLCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.75
p.A16V	TCGA-CD-A4MJ	STAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.A16V	TCGA-L5-A4OG	ESCA	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.A16V	DO47811	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.V466A	TCGA-CN-4738	HNSC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6936
p.V466A	DO14214	HNSC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6936
p.G626E	TCGA-D3-A3MU	SKCM	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7199
p.G626E	DO47337	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7199
p.E472K	TCGA-DA-A1HV	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.E472K	TCGA-FW-A3R5	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.E472K	DO220899	MELA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.E472K	DO222395	MELA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.E472K	DO37659	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.E472K	DO37406	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.K625N	TCGA-DG-A2KK	CESC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.6918
p.K625N	DO51595	CESC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.6918
p.C617S	TCGA-DM-A28G	COAD	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1944
p.C617S	DO10750	COAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1944
p.R390G	TCGA-EA-A43B	CESC	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.3056
p.R390G	DO44384	CESC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.3056
p.G962E	TCGA-EE-A29D	SKCM	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1389
p.G962E	DO222395	MELA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1389
p.G962E	DO38123	SKCM	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1389
p.N375H	TCGA-EO-A22R	UCEC	TCGA	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.0833
p.N375H	DO42713	UCEC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.0833
p.R636K	TCGA-FR-A726	SKCM	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0833
p.R636K	DO48665	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0833
p.S945L	TCGA-FR-A728	SKCM	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2222
p.S945L	DO48550	SKCM	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2222
p.P462S	TCGA-FS-A1ZK	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.P462S	DO37474	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.R479M	TCGA-FS-A1ZM	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.R479M	DO37731	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.R615W	TCGA-GF-A6C9	SKCM	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1389
p.R615W	DO51254	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1389
p.V939L	TCGA-HU-8602	STAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.0556
p.V939L	DO47829	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.0556
p.Q19E	TCGA-JW-A5VL	CESC	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.Q19E	DO49976	CESC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.P637T	TCGA-NC-A5HT	LUSC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0556
p.P637T	DO219205	LUSC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0556
p.P15L	TCGA-RD-A8NB	STAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.6471
p.P15L	DO50142	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.6471
p.I620V	TCGA-UB-A7ME	LIHC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.I620V	DO52321	LIHC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.R987P	TCGA-W3-A828	SKCM	TCGA	DYR	CBL_MET	986:988	Mutation altering degron motif	0.7512
p.R987P	DO51273	SKCM	ICGC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.7512
p.D380N	DO1094	BRCA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.R993S	DO2341	BRCA	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1944
p.N961K	DO4092	BRCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1667
p.I982V	DO222756	BTCA	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2222
p.R18C	DO222892	BTCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.R18C	DO234154	ESAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.R965G	DO222946	BTCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation substituting flanking lysine	0.1667
p.R14L	DO49886	CESC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.8428
p.V20F	DO10092	COAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1944
p.H984R	DO8264	COAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.2778
p.R993I	DO8264	COAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1944
p.K624N	DO8264	COAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.6918
p.R957C	DO230334	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2778
p.R957C	DO229003	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2778
p.R957C	DO229005	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2778
p.R957C	DO229047	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2778
p.N11D	DO222762	COCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.6932
p.V5I	DO222769	COCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.P958S	DO222864	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.25
p.P958S	DO36881	READ	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.25
p.R382G	DO222884	COCA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.D461Y	DO222849	COCA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.25
p.V20G	DO219910	DLBC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1944
p.V20G	DO233213	GACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1944
p.K468T	DO234311	ESAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7306
p.N480T	DO234311	ESAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0556
p.R14S	DO234446	ESAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7427
p.L635V	DO222645	ESCA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1111
p.R22W	DO218693	GACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1389
p.M989K	DO233130	GACA	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.3056
p.T5A	DO233156	GACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.Q375E	DO233223	GACA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.0833
p.G383C	DO233222	GACA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.3056
p.G383V	DO233652	GACA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.3056
p.E612V	DO233662	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0556
p.E472G	DO233732	GACA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.V632A	DO233747	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1944
p.E388D	DO11651	GBM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.6758
p.E388D	DO43202	UCEC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.6758
p.E388D	SIDM01090	Colorectal Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.6758
p.E388D	ACH-000943	Colon/Colorectal Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.6758
p.E388D	RKO	large intestine	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.6758
p.R944C	DO14678	HNSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.6389
p.R944C	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.6389
p.R944C	EN	endometrium	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.6389
p.A11S	DO15238	HNSC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.G382D	DO52070	HNSC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.G7R	DO231979	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7568
p.N947K	DO228559	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2778
p.C5F	DO228952	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.S24I	DO228974	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0833
p.W392C	DO228976	LICA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.R10L	DO229028	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7316
p.R10L	DO229038	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7316
p.E996D	DO229034	LICA	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.1111
p.G5V	DO229034	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.R382M	DO229036	LICA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.R944L	DO229041	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.6389
p.A9S	DO229045	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.S18Y	DO229047	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.M378K	DO231602	LINC	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.E377Q	DO48751	LIRI	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.H16N	DO24596	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.G959A	DO24547	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2222
p.V989L	DO25320	LUAD	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.3056
p.Q396L	DO45346	LUAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.R18S	DO45328	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.I964T	DO26042	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.0833
p.G19V	DO25010	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.G19V	DO40884	UCEC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.G19V	DO41211	UCEC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.G6V	DO231152	LUSC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.S941I	DO27413	LUSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1111
p.G991R	DO52683	MALY	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.25
p.R471W	DO220898	MELA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.3056
p.E379K	DO222396	MELA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1944
p.E991K	DO222572	MELA	ICGC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.25
p.E387Q	DO29258	OV	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.6744
p.R18H	DO49178	PACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.R944H	DO49135	PACA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation blocking phosphorylation signal	0.6389
p.R22Q	DO35242	PACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1389
p.S393Y	DO36881	READ	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.S398L	DO218880	SKCA	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.0833
p.G960E	DO37831	SKCM	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1944
p.G960E	ACH-000426	Myeloma	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1944
p.G960E	ACH-001543	Head and Neck Cancer	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1944
p.G960E	KOSC-2	upper aerodigestive tract	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1944
p.E377K	DO37831	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.E377K	DO51254	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.E377K	Daudi	haematopoietic and lymphoid tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.G382S	DO37996	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.K398N	DO37971	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.0833
p.P395S	DO47359	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.P395L	DO47359	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.H16Y	DO51246	SKCM	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.G382V	DO38479	STAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.V953A	DO51761	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.6936
p.Q396R	DO38679	STAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.A12V	DO47807	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.5825
p.K963N	DO47769	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1111
p.Q17K	DO47925	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.L22R	DO229253	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1389
p.G7V	DO229272	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7532
p.S24C	DO229216	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0833
p.A12T	DO229216	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.6028
p.Q17L	DO229232	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.S997R	SIDM01271	Esophageal Carcinoma	GDSC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.0833
p.Q2H	SIDM02021	Esophageal Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1944
p.F21Y	SIDM00455	Pancreatic Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1667
p.F21Y	ACH-000599	Pancreatic Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1667
p.F21Y	PA-TU-8902	pancreas	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1667
p.S23I	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1111
p.M378R	SIDM00845	Burkitt's Lymphoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.M378R	Daudi	haematopoietic and lymphoid tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.F381Y	SIDM00845	Burkitt's Lymphoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.F381Y	Daudi	haematopoietic and lymphoid tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.R382S	SIDM00064	Hepatocellular Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.R382S	SIDM00587	Biliary Tract Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.R382S	SIDM00280	Gastric Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.R382S	HuCCT1	biliary tract	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.R382S	ECC10	stomach	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.R382S	HLE	liver	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.N11S	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7069
p.N11S	ACH-000693	Esophageal Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7069
p.N11S	KYSE-180	oesophagus	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7069
p.F3S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.F3S	ACH-002256	Leukemia	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.H458N	SIDM00583	Pancreatic Carcinoma	GDSC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1667
p.H458N	KP-1N	pancreas	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1667
p.A629S	SIDM00583	Pancreatic Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.A629S	KP-1N	pancreas	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.P395T	SIDM00812	Colorectal Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.P395T	ACH-000236	Colon/Colorectal Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.P395T	SW1417	large intestine	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.G614D	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1111
p.G614D	NCI-H661	lung	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1111
p.G5C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.A629V	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.A629V	SK-LU-1	lung	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.H18Y	SIDM00151	Ovarian Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.H18Y	ACH-000966	Ovarian Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.H18Y	IGROV-1	ovary	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.M16V	SIDM00251	Gastric Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.M16V	ACH-000949	Gastric Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.M16V	TGBC11TKB	stomach	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.H948Y	SIDM00342	T-Lymphoblastic Leukemia	GDSC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.3056
p.H948Y	SIDM00261	Ewing's Sarcoma	GDSC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.3056
p.Q19H	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.Q19H	ACH-000544	Esophageal Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.Q19H	OE21	oesophagus	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.R393K	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.R393K	BC-1	haematopoietic and lymphoid tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.G962V	SIDM01653	Non-Cancerous	GDSC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1389
p.D630N	SIDM00685	Glioblastoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.25
p.D630N	LN-18	central nervous system	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.25
p.T986A	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.7139
p.T986A	HCC2998	large intestine	COSMIC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.7139
p.T986A	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.7139
p.R8P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7512
p.R8P	ACH-002222	Leukemia	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7512
p.H16D	SIDM00937	Oral Cavity Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.H16D	ACH-000832	Head and Neck Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.H16D	CAL-27	upper aerodigestive tract	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.T631N	SIDM01503	Small Cell Lung Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2222
p.K473N	SIDM00192	Colorectal Carcinoma	GDSC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.25
p.R455W	SIDM00162	Biliary Tract Carcinoma	GDSC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0833
p.M378V	ACH-000209	Bile Duct Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1667
p.M388I	ACH-000395	Lung Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.7618
p.M388I	NCI-H520	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.7618
p.P15Q	ACH-000826	Lung Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.5924
p.P15Q	CAL-12T	lung	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.5924
p.G392D	ACH-000853	Lung Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.G392D	NCI-H661	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.T948I	ACH-001050	Sarcoma	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.3056
p.Q10L	ACH-001345	Colon/Colorectal Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7765
p.S949N	ACH-002080	Neuroblastoma	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation altering degron motif	0.7069
p.A377P	ACH-002358	Non-Cancerous	CCLE	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.G469D	NCI-H661	lung	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7198
p.R958L	TGBC11TKB	stomach	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.25
p.M465I	NCI-H520	lung	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7618
p.P620S	H9	haematopoietic and lymphoid tissue	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.2778
p.R637I	HT-115	large intestine	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.0556
p.L625I	NCI-H630	large intestine	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation altering degron motif	0.7174
p.T961A	HCC2998	large intestine	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.1667
p.A945T	HCC2157	breast	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	949:955	Mutation rewiring degron network	0.2222
p.R983L	TGBC11TKB	stomach	COSMIC	DYR	CBL_MET	986:988	Mutation rewiring degron network	0.25
p.N634Y	NCI-H2291	lung	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	622:627	Mutation rewiring degron network	0.1389
p.L470I	KYSE-140	oesophagus	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7174
p.V375L	NCI-H650	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.0833
p.F987L	JAR	placenta	COSMIC	DYR	CBL_MET	986:988	Mutation altering degron motif	0.6981
p.L456Q	HCC70	breast	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIMS2

UniProt ID: Q9UQ26

Entrez ID: 9699

Protein name: Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIMS2 in