DegronMD

Uniprot ID: Q9UQ26

Source protein: Regulating synaptic membrane exocytosis protein 2

Source gene: RIMS2

Class: LIG_APCC_ABBAyCdc20_2

Location: 949:955

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8882

ASA_SCORE: 100.6714

COIL: 0.7464

CONS_SCORE: 0.4687

DSS_SCORE: 0.7119

HELIX: 0.2019

FCONS_SCORE: 1.0095

RIG_SCORE: 0.6271

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G953W	TCGA-33-4532	LUSC	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7825
p.G953W	TCGA-A5-A0G2	UCEC	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7825
p.G953W	DO26626	LUSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7825
p.G953W	DO41235	UCEC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7825
p.P955H	TCGA-43-5668	LUSC	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7694
p.P955H	TCGA-55-8620	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7694
p.P955H	DO228609	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7694
p.P955H	DO24547	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7694
p.P955H	DO26608	LUSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7694
p.G962R	TCGA-50-6590	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G962R	DO24692	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R965I	TCGA-55-8616	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R965I	TCGA-HU-8604	STAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R965I	DO23566	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R965I	DO47907	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P955T	TCGA-55-8620	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7031
p.P955T	DO24547	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7031
p.I961M	TCGA-91-6836	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.I961M	DO23854	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P955S	TCGA-99-8028	LUAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6752
p.P955S	DO23561	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6752
p.H956D	TCGA-BT-A0YX	BLCA	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.75
p.H956D	DO516	BLCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.75
p.G962E	TCGA-EE-A29D	SKCM	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G962E	DO222395	MELA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G962E	DO38123	SKCM	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S945L	TCGA-FR-A728	SKCM	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S945L	DO48550	SKCM	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V939L	TCGA-HU-8602	STAD	TCGA	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V939L	DO47829	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.N961K	DO4092	BRCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R965G	DO222946	BTCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R957C	DO230334	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R957C	DO229003	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R957C	DO229005	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R957C	DO229047	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P958S	DO222864	COCA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.P958S	DO36881	READ	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.R944C	DO14678	HNSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6389
p.R944C	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6389
p.R944C	EN	endometrium	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6389
p.N947K	DO228559	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R944L	DO229041	LICA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6389
p.G959A	DO24547	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I964T	DO26042	LUAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S941I	DO27413	LUSC	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R944H	DO49135	PACA	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6389
p.G960E	DO37831	SKCM	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G960E	ACH-000426	Myeloma	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G960E	ACH-001543	Head and Neck Cancer	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G960E	KOSC-2	upper_aerodigestive_tract	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V953A	DO51761	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.6936
p.K963N	DO47769	STAD	ICGC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H948Y	SIDM00342	T-Lymphoblastic Leukemia	GDSC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.H948Y	SIDM00261	Ewing's Sarcoma	GDSC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G962V	SIDM01653	Non-Cancerous	GDSC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T948I	ACH-001050	Sarcoma	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S949N	ACH-002080	Neuroblastoma	CCLE	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.7069
p.R958L	TGBC11TKB	stomach	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.T961A	HCC2998	large_intestine	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A945T	HCC2157	breast	COSMIC	RRQLHGE	LIG_APCC_ABBAyCdc20_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRQLHGE

Degron related mutations and impact score

Drug responses associated with RIMS2 mutations

All proteins holding degron of RRQLHGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	LIG_APCC_ABBAyCdc20_2	949:955	RRQLHGE	APC,CDC20,FZR1	0.8882	More...