DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DYR
Uniprot ID:
Q9UQ26
Source protein:
Regulating synaptic membrane exocytosis protein 2
Source gene:
RIMS2
Class:
CBL_MET
Location:
986:988
E3 ligase:
CBL
DEGRON score:
0.5284
ASA_SCORE:
66.1333
COIL:
0.4657
CONS_SCORE:
0.4386
DSS_SCORE:
0.5267
HELIX:
0.0577
FCONS_SCORE:
0.9168
RIG_SCORE:
0.7698
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R987L
TCGA-17-Z042
LUAD
TCGA
DYR
CBL_MET
0.8428
p.R987L
DO227564
PACA
ICGC
DYR
CBL_MET
0.8428
p.R987C
TCGA-AX-A1CE
UCEC
TCGA
DYR
CBL_MET
0.8301
p.R987C
DO42280
UCEC
ICGC
DYR
CBL_MET
0.8301
p.R987H
TCGA-BR-4368
STAD
TCGA
DYR
CBL_MET
0.8244
p.R987H
TCGA-D5-6928
COAD
TCGA
DYR
CBL_MET
0.8244
p.R987H
DO7776
COAD
ICGC
DYR
CBL_MET
0.8244
p.R987H
DO38715
STAD
ICGC
DYR
CBL_MET
0.8244
p.R987P
TCGA-W3-A828
SKCM
TCGA
DYR
CBL_MET
0.7512
p.R987P
DO51273
SKCM
ICGC
DYR
CBL_MET
0.7512
p.T986A
SIDM00217
Colorectal Carcinoma
GDSC
DYR
CBL_MET
0.7139
p.T986A
HCC2998
large_intestine
COSMIC
DYR
CBL_MET
0.7139
p.T986A
SNU-1040
large_intestine
COSMIC
DYR
CBL_MET
0.7139
p.F987L
JAR
placenta
COSMIC
DYR
CBL_MET
0.6981
p.M989K
DO233130
GACA
ICGC
DYR
CBL_MET
0.3056
p.V989L
DO25320
LUAD
ICGC
DYR
CBL_MET
0.3056
p.R984Q
TCGA-AG-A002
READ
TCGA
DYR
CBL_MET
0.2778
p.R984Q
TCGA-BR-8361
STAD
TCGA
DYR
CBL_MET
0.2778
p.R984Q
DO48032
STAD
ICGC
DYR
CBL_MET
0.2778
p.H984R
DO8264
COAD
ICGC
DYR
CBL_MET
0.2778
p.G991E
TCGA-49-6767
LUAD
TCGA
DYR
CBL_MET
0.25
p.G991E
DO23586
LUAD
ICGC
DYR
CBL_MET
0.25
p.G991R
DO52683
MALY
ICGC
DYR
CBL_MET
0.25
p.E991K
DO222572
MELA
ICGC
DYR
CBL_MET
0.25
p.R983L
TGBC11TKB
stomach
COSMIC
DYR
CBL_MET
0.25
Showing 1 to 25 of 56 entries
Previous
1
2
3
Next
Drug responses associated with RIMS2 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of DYR
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y2I7
1-phosphatidylinositol 3-phosphate 5-kinase
CBL_MET
1154:1156
DYR
CBL
0.9899
More...
P62333
26S proteasome regulatory subunit 10B
CBL_MET
11:13
DYR
CBL
0.5589
More...
Q96A35
39S ribosomal protein L24, mitochondrial
CBL_MET
103:105
DYR
CBL
0.8186
More...
Q9P2N4
A disintegrin and metalloproteinase with thrombospondin motifs 9
CBL_MET
1313:1315
DYR
CBL
0.9337
More...
Q12802
A-kinase anchor protein 13
CBL_MET
823:825
DYR
CBL
0.8159
More...
Q96K21
Abscission/NoCut checkpoint regulator
CBL_MET
348:350
DYR
CBL
0.5257
More...
P40145
Adenylate cyclase type 8
CBL_MET
1148:1150
DYR
CBL
0.7268
More...
P51825
AF4/FMR2 family member 1
CBL_MET
316:318
DYR
CBL
0.9069
More...
Q9P0K7
Ankycorbin
CBL_MET
661:663
DYR
CBL
0.6245
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
864:866
DYR
CBL
0.5334
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
899:901
DYR
CBL
0.7809
More...
Q96NW4
Ankyrin repeat domain-containing protein 27
CBL_MET
666:668
DYR
CBL
0.9069
More...
Q8N944
APC membrane recruitment protein 3
CBL_MET
128:130
DYR
CBL
0.9544
More...
Q9BZC7
ATP-binding cassette sub-family A member 2
CBL_MET
1395:1397
DYR
CBL
0.9909
More...
Q08211
ATP-dependent RNA helicase A
CBL_MET
1233:1235
DYR
CBL
0.9757
More...
O00571
ATP-dependent RNA helicase DDX3X
CBL_MET
601:603
DYR
CBL
0.9982
More...
O15523
ATP-dependent RNA helicase DDX3Y
CBL_MET
599:601
DYR
CBL
0.9998
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
56:58
DYR
CBL
0.7315
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
60:62
DYR
CBL
0.9219
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
407:409
DYR
CBL
0.8675
More...
A2AJT9
BCLAF1 and THRAP3 family member 3
CBL_MET
280:282
DYR
CBL
0.8797
More...
Q9NWK9
Box C/D snoRNA protein 1
CBL_MET
277:279
DYR
CBL
0.8233
More...
Q9NSI6
Bromodomain and WD repeat-containing protein 1
CBL_MET
563:565
DYR
CBL
0.9622
More...
P25440
Bromodomain-containing protein 2
CBL_MET
407:409
DYR
CBL
0.9586
More...
Q2TAL6
Brorin
CBL_MET
149:151
DYR
CBL
0.987
More...
Showing 1 to 25 of 231 entries
Previous
1
2
3
4
5
…
10
Next
