DegronMD - Q08378(GOLGA3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L880M	TCGA-19-2621	GBM	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.25
p.L880M	DO11100	GBM	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.25
p.N258T	TCGA-24-1423	OV	TCGA	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1111
p.N258T	DO30080	OV	ICGC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1111
p.G892V	TCGA-58-A46M	LUSC	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.3056
p.G892V	DO45485	LUSC	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.3056
p.S240P	TCGA-AJ-A3EL	UCEC	TCGA	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1111
p.S240P	DO41542	UCEC	ICGC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1111
p.R884W	TCGA-BG-A3EW	UCEC	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.8634
p.R884W	DO48172	UCEC	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.8634
p.S259Y	TCGA-DK-A6AW	BLCA	TCGA	DYR	CBL_MET	248:250	Mutation blocking phosphorylation signal	0.5278
p.S259Y	DO48566	BLCA	ICGC	DYR	CBL_MET	248:250	Mutation blocking phosphorylation signal	0.5278
p.R244W	TCGA-EE-A2MR	SKCM	TCGA	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.2222
p.R244W	DO222731	MELA	ICGC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.2222
p.R244W	DO37819	SKCM	ICGC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.2222
p.E893Q	TCGA-L5-A8NK	ESCA	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.R873S	TCGA-L5-A8NK	ESCA	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.0556
p.A899V	TCGA-VQ-A8E3	STAD	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.A899V	DO51759	STAD	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.K242E	TCGA-VR-A8EY	ESCA	TCGA	DYR	CBL_MET	248:250	Mutation substituting flanking lysine	0.2778
p.S878L	DO228935	COCA	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation blocking phosphorylation signal	0.6389
p.S878L	DO222477	ESCA	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation blocking phosphorylation signal	0.6389
p.S878L	SIDM00251	Gastric Carcinoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation blocking phosphorylation signal	0.6389
p.S878L	ACH-000949	Gastric Cancer	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation blocking phosphorylation signal	0.6389
p.S878L	TGBC11TKB	stomach	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation blocking phosphorylation signal	0.6389
p.D248N	DO222778	COCA	ICGC	DYR	CBL_MET	248:250	Mutation altering degron motif	0.6932
p.R895W	DO234285	ESAD	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2222
p.G892R	DO233670	GACA	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.3056
p.R895Q	SIDM00074	Burkitt's Lymphoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2222
p.R895Q	ACH-000402	Lymphoma	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2222
p.R895Q	BL-70	haematopoietic and lymphoid tissue	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2222
p.H891R	SIDM00683	Prostate Carcinoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.7133
p.H891R	ACH-000977	lymph node	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.7133
p.H891R	LNCaP-Clone-FGC	prostate	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.7133
p.K874R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation substituting flanking lysine	0.1944
p.K874R	ACH-002256	Leukemia	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation substituting flanking lysine	0.1944
p.K874R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation substituting flanking lysine	0.1944
p.K881N	SIDM00151	Ovarian Carcinoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.K881N	ACH-000966	Ovarian Cancer	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.K881N	IGROV-1	ovary	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.D248Y	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	248:250	Mutation altering degron motif	0.7325
p.D248Y	ACH-000900	Lung Cancer	CCLE	DYR	CBL_MET	248:250	Mutation altering degron motif	0.7325
p.D248Y	NCI-H23	lung	COSMIC	DYR	CBL_MET	248:250	Mutation altering degron motif	0.7325
p.A256V	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1667
p.A256V	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1667
p.A256V	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.1667
p.R250I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	248:250	Mutation altering degron motif	0.8102
p.R250I	ACH-001127	Leukemia	CCLE	DYR	CBL_MET	248:250	Mutation altering degron motif	0.8102
p.R250I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	248:250	Mutation altering degron motif	0.8102
p.R250T	SIDM01502	Endometrial Carcinoma	GDSC	DYR	CBL_MET	248:250	Mutation altering degron motif	0.7876
p.R250T	ACH-000435	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	248:250	Mutation altering degron motif	0.7876
p.S245Y	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.25
p.S245Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	248:250	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GOLGA3

UniProt ID: Q08378

Entrez ID: 2802

Protein name: Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GOLGA3 in