DegronMD

Uniprot ID: Q08378

Source protein: Golgin subfamily A member 3

Source gene: GOLGA3

Class: DEG_APCC_DBOX_1

Location: 883:891

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7733

ASA_SCORE: 106.4

COIL: 0.0313

CONS_SCORE: 0.7083

DSS_SCORE: 0.4492

HELIX: 0.9679

FCONS_SCORE: 0.995

RIG_SCORE: 0.7523

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L880M	TCGA-19-2621	GBM	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	0.25
p.L880M	DO11100	GBM	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.25
p.G892V	TCGA-58-A46M	LUSC	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	0.3056
p.G892V	DO45485	LUSC	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.3056
p.R884W	TCGA-BG-A3EW	UCEC	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	0.8634
p.R884W	DO48172	UCEC	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.8634
p.E893Q	TCGA-L5-A8NK	ESCA	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	0.2778
p.R873S	TCGA-L5-A8NK	ESCA	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	0.0556
p.A899V	TCGA-VQ-A8E3	STAD	TCGA	LRQELMQVH	DEG_APCC_DBOX_1	0.1111
p.A899V	DO51759	STAD	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.1111
p.S878L	DO228935	COCA	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.6389
p.S878L	DO222477	ESCA	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.6389
p.S878L	SIDM00251	Gastric Carcinoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	0.6389
p.S878L	ACH-000949	Gastric Cancer	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	0.6389
p.S878L	TGBC11TKB	stomach	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	0.6389
p.R895W	DO234285	ESAD	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.2222
p.G892R	DO233670	GACA	ICGC	LRQELMQVH	DEG_APCC_DBOX_1	0.3056
p.R895Q	SIDM00074	Burkitt's Lymphoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	0.2222
p.R895Q	ACH-000402	Lymphoma	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	0.2222
p.R895Q	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	0.2222
p.H891R	SIDM00683	Prostate Carcinoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	0.7133
p.H891R	ACH-000977	lymph_node	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	0.7133
p.H891R	LNCaP-Clone-FGC	prostate	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	0.7133
p.K874R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	0.1944
p.K874R	ACH-002256	Leukemia	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	0.1944
p.K874R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	0.1944
p.K881N	SIDM00151	Ovarian Carcinoma	GDSC	LRQELMQVH	DEG_APCC_DBOX_1	0.2778
p.K881N	ACH-000966	Ovarian Cancer	CCLE	LRQELMQVH	DEG_APCC_DBOX_1	0.2778
p.K881N	IGROV-1	ovary	COSMIC	LRQELMQVH	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRQELMQVH

Degron related mutations and impact score

Drug responses associated with GOLGA3 mutations

All proteins holding degron of LRQELMQVH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08378	Golgin subfamily A member 3	DEG_APCC_DBOX_1	883:891	LRQELMQVH	APC,CDC20,FZR1	0.7733	More...