DegronMD - Q9NRA8(EIF4ENIF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R944C	TCGA-24-2260	OV	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1667
p.R944C	TCGA-95-A4VK	LUAD	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1667
p.R776H	TCGA-2J-AAB6	PAAD	TCGA	DYR	CBL_MET	782:784	Mutation rewiring degron network	0.1667
p.R776H	TCGA-PN-A8MA	CESC	TCGA	DYR	CBL_MET	782:784	Mutation rewiring degron network	0.1667
p.E942Q	TCGA-63-A5MH	LUSC	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2222
p.S349I	TCGA-66-2783	LUSC	TCGA	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation rewiring degron network	0.1944
p.S772Y	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	782:784	Mutation blocking phosphorylation signal	0.5
p.Q731E	TCGA-AC-A23H	BRCA	TCGA	SSSSVPSA	DEG_COP1_1	740:747	Mutation rewiring degron network	0.0833
p.A747V	TCGA-AD-6889	COAD	TCGA	SSSSVPSA	DEG_COP1_1	740:747	Mutation altering degron motif	0.5825
p.T754I	TCGA-AD-A5EJ	COAD	TCGA	SSSSVPSA	DEG_COP1_1	740:747	Mutation blocking phosphorylation signal	0.5833
p.S752F	TCGA-B5-A11E	UCEC	TCGA	SSSSVPSA	DEG_COP1_1	740:747	Mutation blocking phosphorylation signal	0.6389
p.R776C	TCGA-B5-A1MX	UCEC	TCGA	DYR	CBL_MET	782:784	Mutation rewiring degron network	0.1667
p.R776C	SIDM02035	Colorectal Carcinoma	GDSC	DYR	CBL_MET	782:784	Mutation rewiring degron network	0.1667
p.R350Q	TCGA-CG-4441	STAD	TCGA	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation rewiring degron network	0.2222
p.R931L	TCGA-D3-A2JP	SKCM	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.8428
p.S757Y	TCGA-G2-A2EJ	BLCA	TCGA	SSSSVPSA	DEG_COP1_1	740:747	Mutation rewiring degron network	0.0556
p.P929L	TCGA-LN-A9FO	ESCA	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.3056
p.M360V	DO708	BLCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.7208
p.R358C	DO3940	BRCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.8301
p.R358C	DO41572	UCEC	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.8301
p.R358H	DO10582	COAD	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.8244
p.R358H	DO230312	COCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.8244
p.Y361F	DO229213	THCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.7528
p.I351T	DO41235	UCEC	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation blocking phosphorylation signal	0.6944
p.L347I	DO42472	UCEC	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation rewiring degron network	0.1389
p.P945T	SIDM00845	Burkitt's Lymphoma	GDSC	SRSGLPHMH	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1389
p.P358T	SIDM00465	Ovarian Carcinoma	GDSC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.7031
p.P358T	OVMIU	ovary	COSMIC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.7031
p.G355W	SIDM00878	Breast Carcinoma	GDSC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.6714
p.G355W	HCC1569	breast	COSMIC	LGSTPHEE	DEG_SCF_FBW7_2	354:361	Mutation altering degron motif	0.6714
p.P745H	SIDM00217	Colorectal Carcinoma	GDSC	SSSSVPSA	DEG_COP1_1	740:747	Mutation altering degron motif	0.7694
p.P745H	SNU-1040	large intestine	COSMIC	SSSSVPSA	DEG_COP1_1	740:747	Mutation altering degron motif	0.7694
p.R730C	ACH-000953	Leukemia	CCLE	SSSSVPSA	DEG_COP1_1	740:747	Mutation rewiring degron network	0.0556
p.R730C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SSSSVPSA	DEG_COP1_1	740:747	Mutation rewiring degron network	0.0556
p.S777F	ACH-001407	Bladder Cancer	CCLE	DYR	CBL_MET	782:784	Mutation rewiring degron network	0.1944
p.R757W	ACH-001518	Endometrial/Uterine Cancer	CCLE	SSSSVPSA	DEG_COP1_1	740:747	Mutation rewiring degron network	0.0556
p.V775I	SNU-C2B	large intestine	COSMIC	DYR	CBL_MET	782:784	Mutation rewiring degron network	0.1389
p.H792R	TGBC11TKB	stomach	COSMIC	DYR	CBL_MET	782:784	Mutation blocking phosphorylation signal	0.5556
p.R782C	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	782:784	Mutation altering degron motif	0.8301

Kaplan plot for EIF4ENIF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF4ENIF1

UniProt ID: Q9NRA8

Entrez ID: 56478

Protein name: Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF4ENIF1 in