DegronMD

Uniprot ID: Q9NRA8

Source protein: Eukaryotic translation initiation factor 4E transporter

Source gene: EIF4ENIF1

Class: DEG_APCC_DBOX_1

Location: 930:938

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8876

ASA_SCORE: 91.3667

COIL: 0.8799

CONS_SCORE: 0.416

DSS_SCORE: 0.7414

HELIX: 0.0797

FCONS_SCORE: 1.0255

RIG_SCORE: 0.5944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R944C	TCGA-24-2260	OV	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	0.1667
p.R944C	TCGA-95-A4VK	LUAD	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	0.1667
p.E942Q	TCGA-63-A5MH	LUSC	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	0.2222
p.R931L	TCGA-D3-A2JP	SKCM	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	0.8428
p.P929L	TCGA-LN-A9FO	ESCA	TCGA	SRSGLPHMH	DEG_APCC_DBOX_1	0.3056
p.P945T	SIDM00845	Burkitt's Lymphoma	GDSC	SRSGLPHMH	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRA8	Eukaryotic translation initiation factor 4E transporter	DEG_APCC_DBOX_1	930:938	SRSGLPHMH	APC,CDC20,FZR1	0.8876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons