DegronMD

Uniprot ID: Q9NRA8

Source protein: Eukaryotic translation initiation factor 4E transporter

Source gene: EIF4ENIF1

Class: DEG_SCF_FBW7_2

Location: 354:361

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 82.4875

COIL: 0.5581

CONS_SCORE: 0.6463

DSS_SCORE: 0.5763

HELIX: 0.4328

FCONS_SCORE: 1.3377

RIG_SCORE: 0.6131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S349I	TCGA-66-2783	LUSC	TCGA	LGSTPHEE	DEG_SCF_FBW7_2	0.1944
p.R350Q	TCGA-CG-4441	STAD	TCGA	LGSTPHEE	DEG_SCF_FBW7_2	0.2222
p.M360V	DO708	BLCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.7208
p.R358C	DO3940	BRCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.8301
p.R358C	DO41572	UCEC	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.8301
p.R358H	DO10582	COAD	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.8244
p.R358H	DO230312	COCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.8244
p.Y361F	DO229213	THCA	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.7528
p.I351T	DO41235	UCEC	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.6944
p.L347I	DO42472	UCEC	ICGC	LGSTPHEE	DEG_SCF_FBW7_2	0.1389
p.P358T	SIDM00465	Ovarian Carcinoma	GDSC	LGSTPHEE	DEG_SCF_FBW7_2	0.7031
p.P358T	OVMIU	ovary	COSMIC	LGSTPHEE	DEG_SCF_FBW7_2	0.7031
p.G355W	SIDM00878	Breast Carcinoma	GDSC	LGSTPHEE	DEG_SCF_FBW7_2	0.6714
p.G355W	HCC1569	breast	COSMIC	LGSTPHEE	DEG_SCF_FBW7_2	0.6714

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRA8	Eukaryotic translation initiation factor 4E transporter	DEG_SCF_FBW7_2	354:361	LGSTPHEE	FBXW7	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons