DegronMD

Uniprot ID: Q9NRA8

Source protein: Eukaryotic translation initiation factor 4E transporter

Source gene: EIF4ENIF1

Class: DEG_COP1_1

Location: 740:747

E3 ligase: COP1

DEGRON score: 0.9425

ASA_SCORE: 87.4625

COIL: 0.9363

CONS_SCORE: 0.3562

DSS_SCORE: 0.6767

HELIX: 0.0478

FCONS_SCORE: 0.9421

RIG_SCORE: 0.5849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q731E	TCGA-AC-A23H	BRCA	TCGA	SSSSVPSA	DEG_COP1_1	0.0833
p.A747V	TCGA-AD-6889	COAD	TCGA	SSSSVPSA	DEG_COP1_1	0.5825
p.T754I	TCGA-AD-A5EJ	COAD	TCGA	SSSSVPSA	DEG_COP1_1	0.5833
p.S752F	TCGA-B5-A11E	UCEC	TCGA	SSSSVPSA	DEG_COP1_1	0.6389
p.S757Y	TCGA-G2-A2EJ	BLCA	TCGA	SSSSVPSA	DEG_COP1_1	0.0556
p.P745H	SIDM00217	Colorectal Carcinoma	GDSC	SSSSVPSA	DEG_COP1_1	0.7694
p.P745H	SNU-1040	large_intestine	COSMIC	SSSSVPSA	DEG_COP1_1	0.7694
p.R730C	ACH-000953	Leukemia	CCLE	SSSSVPSA	DEG_COP1_1	0.0556
p.R730C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SSSSVPSA	DEG_COP1_1	0.0556
p.R757W	ACH-001518	Endometrial/Uterine Cancer	CCLE	SSSSVPSA	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRA8	Eukaryotic translation initiation factor 4E transporter	DEG_COP1_1	740:747	SSSSVPSA	COP1	0.9425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons