DegronMD - Q6V1P9(DCHS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H265P	TCGA-05-4418	LUAD	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0556
p.H265P	DO23814	LUAD	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0556
p.F1750I	TCGA-06-5416	GBM	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.2778
p.F1750I	DO10880	GBM	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.2778
p.L1748I	TCGA-17-Z001	LUAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.2222
p.L1748P	TCGA-17-Z031	LUAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.2222
p.L1761F	TCGA-38-4629	LUAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.2222
p.L1761F	DO23771	LUAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.2222
p.V878F	TCGA-44-3918	LUAD	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1944
p.K965N	TCGA-4Z-AA7M	BLCA	TCGA	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.K965N	DO218976	BLCA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.S884L	TCGA-66-2785	LUSC	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.7667
p.R128S	TCGA-77-A5G8	LUSC	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.A276V	TCGA-A5-A0G1	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6936
p.A276V	DO42472	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6936
p.F287L	TCGA-A5-A2K5	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.2222
p.F287L	DO41379	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.2222
p.R129W	TCGA-A6-2686	COAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1111
p.R129W	TCGA-EO-A22U	UCEC	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1111
p.R129W	TCGA-G4-6628	COAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1111
p.A895T	TCGA-AA-A010	COAD	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1389
p.A895T	DO222492	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1389
p.K250N	TCGA-AG-A002	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.R126H	TCGA-AJ-A3EK	UCEC	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.A1371T	TCGA-AX-A0J1	UCEC	TCGA	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1944
p.A1371T	DO50855	LIRI	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1944
p.A1371T	DO41199	UCEC	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1944
p.A1371T	ACH-000933	Pancreatic Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1944
p.D169Y	TCGA-AX-A0J1	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.7325
p.N161H	TCGA-AZ-4315	COAD	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.2222
p.S949Y	TCGA-B5-A0JY	UCEC	TCGA	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.S949Y	TCGA-EO-A22X	UCEC	TCGA	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.S949Y	DO43041	UCEC	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.S949Y	DO43907	UCEC	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.E178K	TCGA-B5-A1MR	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1944
p.G764V	TCGA-BF-A1PZ	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7532
p.G764V	DO50279	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7532
p.H174Y	TCGA-BF-A5ES	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.3056
p.K892N	TCGA-BR-8368	STAD	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2222
p.K892N	DO47981	STAD	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2222
p.D112N	TCGA-BR-8680	STAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2222
p.D112N	TCGA-EO-A22X	UCEC	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2222
p.D112N	ACH-002096	Skin Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2222
p.M288I	TCGA-BS-A0UF	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1944
p.M288I	DO41488	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1944
p.K278T	TCGA-CA-6717	COAD	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7306
p.K278T	DO8264	COAD	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7306
p.L774H	TCGA-CG-4469	STAD	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0833
p.L774H	DO38507	STAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0833
p.S972L	TCGA-D9-A6EC	SKCM	TCGA	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.S972L	DO50291	SKCM	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.E251K	TCGA-DA-A95V	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.E251K	TCGA-FS-A1ZQ	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.E251K	TCGA-GF-A6C9	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.E251K	DO37442	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.E251K	DO51254	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.E251K	DO219478	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.N245S	TCGA-DD-A1EF	LIHC	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.N245S	DO44915	LIHC	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.P168S	TCGA-DF-A2KU	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.5641
p.G116W	TCGA-DK-AA6U	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7825
p.D115E	TCGA-DK-AA6U	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.D757A	TCGA-DM-A1HB	COAD	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7793
p.R110W	TCGA-E9-A1RE	BRCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.D1369N	TCGA-EE-A20C	SKCM	TCGA	DYR	CBL_MET	1364:1366	Mutation blocking phosphorylation signal	0.6944
p.D1369N	DO222775	MELA	ICGC	DYR	CBL_MET	1364:1366	Mutation blocking phosphorylation signal	0.6944
p.D1369N	DO47665	SKCM	ICGC	DYR	CBL_MET	1364:1366	Mutation blocking phosphorylation signal	0.6944
p.P179S	TCGA-EE-A29D	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1667
p.V878A	TCGA-EE-A29M	SKCM	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1944
p.G758C	TCGA-EE-A29Q	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.76
p.G758C	DO37866	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.76
p.E168D	TCGA-EE-A29X	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6758
p.W755L	TCGA-EE-A2GK	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.2778
p.W755L	DO37738	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.2778
p.L241M	TCGA-EO-A3B0	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.711
p.L241M	DO219773	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.711
p.S240L	TCGA-EO-A3B0	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7667
p.S240L	ACH-001842	Bile Duct Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7667
p.K965T	TCGA-EY-A1G8	UCEC	TCGA	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.K965T	DO43578	UCEC	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.G272S	TCGA-EY-A1GF	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.25
p.D894Y	TCGA-GU-A767	BLCA	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.D894Y	DO51892	BLCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.R110Q	TCGA-HC-A6HY	PRAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.R126K	TCGA-LN-A49S	ESCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.K291E	TCGA-MI-A75H	LIHC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1111
p.K291E	DO49710	LIHC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1111
p.Q950E	TCGA-SY-A9G5	BLCA	TCGA	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.Q950E	DO51906	BLCA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.K892Q	TCGA-UY-A78K	BLCA	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2222
p.K892Q	DO219031	BLCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2222
p.K892T	TCGA-V5-A7RB	ESCA	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2222
p.V1760I	TCGA-VQ-A8P2	STAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.25
p.V1760I	TCGA-WS-AB45	COAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.25
p.V1760I	DO51734	COAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.25
p.V1760I	DO51761	STAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.25
p.S1764R	TCGA-VQ-A91V	STAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1389
p.S1764R	DO222356	STAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1389
p.K1746T	TCGA-VQ-A925	STAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.K1746T	DO234462	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.K1746T	DO233736	GACA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.K1746T	DO51796	STAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.D1749H	TCGA-VR-A8EX	ESCA	TCGA	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.25
p.D249E	TCGA-XK-AAIW	PRAD	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1111
p.D249E	DO51407	PRAD	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1111
p.V120F	TCGA-ZF-A9R1	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7068
p.K267M	TCGA-ZF-A9RM	BLCA	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1111
p.K267M	DO219079	BLCA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1111
p.L884I	DO44077	BLCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.6063
p.N973T	DO526	BLCA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.I952T	DO224975	BRCA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.R122W	DO10132	COAD	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.R122W	DO7828	COAD	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.R122W	DO8658	COAD	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.R122W	DO43755	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.I967T	DO7962	COAD	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2222
p.T1364I	DO7783	COAD	ICGC	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.7078
p.R119H	DO230311	COCA	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.8244
p.R119H	DO41584	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.8244
p.V764M	DO230347	COCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.6097
p.V764M	DO234185	ESAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.6097
p.H768R	DO229010	COCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.H768R	DO229003	COCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.H768R	DO230659	LAML	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.H768R	DO231140	LAML	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.H768R	DO230556	LUSC	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.N897S	DO229010	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0833
p.N897S	DO229013	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0833
p.N897S	DO229016	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0833
p.N897S	DO229003	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0833
p.N897S	DO229005	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0833
p.V183G	DO229003	COCA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.V183G	DO230529	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.V183G	DO230535	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.V183G	DO230990	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.V183G	DO231075	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.V183G	DO231049	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.K1746R	DO50452	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.K1746R	DO234453	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.K1746R	DO228305	MALY	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.K1746M	DO234204	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.G758D	DO234204	ESAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7198
p.L774P	DO234269	ESAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0833
p.E887D	DO234330	ESAD	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.5647
p.R126C	DO228542	GACA	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.E1763D	DO233124	GACA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1667
p.V111M	DO233088	GACA	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.E293K	DO233254	GACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0556
p.E293K	DO230449	UTCA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0556
p.V238I	DO233291	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7076
p.R269H	DO233652	GACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1667
p.P174L	DO233791	GACA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.3056
p.L228H	DO233727	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.R123C	DO233885	GACA	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2778
p.V242L	DO20839	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.K1358Q	DO231979	LICA	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1667
p.Y751N	DO228313	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.1667
p.Q1354L	DO228827	LICA	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.0556
p.A761S	DO228844	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7588
p.H890Q	DO228976	LICA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2778
p.F266L	DO229019	LICA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0833
p.H768N	DO229019	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.T1360K	DO229015	LICA	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.2222
p.N772K	DO229015	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.1389
p.D155E	DO229029	LICA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.N966K	DO229036	LICA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.25
p.T775N	DO229036	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0556
p.T1364K	DO229037	LICA	ICGC	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.7306
p.E1744V	DO50835	LICA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.1111
p.R953I	DO50743	LICA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1667
p.R128W	DO219537	LIHC	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.I117T	DO231636	LINC	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7078
p.Y234C	DO25847	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.25
p.P873H	DO24900	LUAD	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.S1355T	DO231204	LUSC	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.0833
p.G749D	DO220862	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.1111
p.R758C	DO220912	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.8301
p.S888F	DO222411	MELA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.7982
p.G764R	DO222775	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7568
p.F280I	DO33624	PACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7415
p.P161L	DO232761	PBCA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.2222
p.T968A	DO229392	PRAD	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.A957T	DO51055	PRAD	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.E762D	DO37595	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.5647
p.D747N	DO51259	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0556
p.P773S	DO38123	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.1111
p.H768Y	DO219456	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.25
p.G955D	DO38551	STAD	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2222
p.P158S	DO38404	STAD	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1389
p.G955S	DO47865	STAD	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2222
p.A747T	DO229253	THCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0556
p.H954Q	DO229216	THCA	ICGC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.A756V	DO229213	THCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.3056
p.N765Y	DO229234	THCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.5948
p.Q1359K	DO229242	THCA	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1944
p.A1371E	DO231353	THCA	ICGC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.1944
p.S233L	DO219773	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.F876C	DO50076	UCEC	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1389
p.P161S	DO223286	UCEC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.2222
p.R129Q	DO43041	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1111
p.E171K	DO41758	UCEC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.7022
p.G265S	DO41704	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0556
p.D248N	DO42608	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.D763Y	DO41199	UCEC	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.6214
p.T181I	SIDM01949	Esophageal Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1111
p.I895T	SIDM00570	Gastric Carcinoma	GDSC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1389
p.I895T	NUGC-4	stomach	COSMIC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1389
p.I1360T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.2222
p.I1360T	KYSE-220	oesophagus	COSMIC	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.2222
p.S171F	SIDM01175	Other Sarcomas	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6871
p.S171F	ACH-002309	Sarcoma	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6871
p.S171F	SW684	soft tissue	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6871
p.V176I	SIDM01169	Ovarian Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.25
p.V176I	TOV-21G	ovary	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.25
p.P111L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.P111L	ACH-000960	Leukemia	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.P111L	REH	haematopoietic and lymphoid tissue	COSMIC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.S107Y	SIDM00329	Hodgkin's Lymphoma	GDSC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.S107Y	ACH-000806	Lymphoma	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.S107Y	L-540	haematopoietic and lymphoid tissue	COSMIC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.D170E	SIDM00264	Ewing's Sarcoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.5647
p.D170E	ACH-002105	Bone Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.5647
p.D170E	ES4	bone	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.5647
p.D971N	SIDM00282	Colorectal Carcinoma	GDSC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.D971N	CW-2	large intestine	COSMIC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.G748W	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0833
p.G748W	NCI-H2023	lung	COSMIC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.0833
p.D1364E	SIDM01088	Endometrial Carcinoma	GDSC	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6758
p.D1364E	RL95-2	endometrium	COSMIC	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6758
p.T3336M	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	3324:3329	Mutation rewiring degron network	0.1389
p.P773L	SIDM00140	Melanoma	GDSC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.1111
p.P773L	COLO-792	skin	COSMIC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation rewiring degron network	0.1111
p.P111Q	SIDM01641	Non-Cancerous	GDSC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.P894L	SIDM00537	Colorectal Carcinoma	GDSC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.P894L	GP5d	large intestine	COSMIC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.P182S	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0833
p.P182S	ACH-000353	Esophageal Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0833
p.P182S	TE-15	oesophagus	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0833
p.M970T	SIDM00783	Colorectal Carcinoma	GDSC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.M970T	HCT-116	large intestine	COSMIC	ACSST	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.F3328L	SIDM01611	Endometrial Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	3324:3329	Mutation altering degron motif	0.587
p.E877K	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.P3330L	SIDM01413	Oral Cavity Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	3324:3329	Mutation rewiring degron network	0.3056
p.P3330S	SIDM01413	Oral Cavity Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	3324:3329	Mutation rewiring degron network	0.3056
p.Q1760R	SIDM01451	Pancreatic Carcinoma	GDSC	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation rewiring degron network	0.25
p.L241V	ACH-000029	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.6765
p.V1364A	ACH-000631	Brain Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.V1364A	ACH-000672	Lung Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.V1364A	ACH-000714	Myeloma	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.V1364A	ACH-000823	Esophageal Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.V1364A	ACH-000993	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.V1364A	ACH-001578	Embryonal Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.V1364A	ACH-001656	Leukemia	CCLE	DYR	CBL_MET	1364:1366	Mutation altering degron motif	0.6936
p.H265Y	ACH-000650	Skin Cancer	CCLE	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0556
p.P181L	ACH-000670	Lung Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1111
p.I118M	ACH-000813	Lung Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7618
p.C1362R	ACH-000888	Lung Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.2778
p.D125Y	ACH-000938	Leukemia	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2222
p.P179L	ACH-000968	Skin Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1667
p.I1360N	ACH-000971	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	1364:1366	Mutation rewiring degron network	0.2222
p.S887G	ACH-000984	Endometrial/Uterine Cancer	CCLE	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.6993
p.Q1757R	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation altering degron motif	0.7329
p.A131T	ACH-000996	Endometrial/Uterine Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.E267K	ACH-001134	Lymphoma	CCLE	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1111
p.K892R	ACH-001417	Lung Cancer	CCLE	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.2222
p.L174F	ACH-001861	Gallbladder Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.3056
p.L961F	ACH-002365	Non-Cancerous	CCLE	ACSST	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCHS2

UniProt ID: Q6V1P9

Entrez ID: 54798

Protein name: Protocadherin-23 (Cadherin-27) (Cadherin-like protein CDHJ) (Cadherin-like protein VR8) (Protein dachsous homolog 2) (Protocadherin PCDHJ)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCHS2 in