DegronMD - Q6V1P9(DCHS2)

FUNCTION: Calcium-dependent cell-adhesion protein. {ECO:0000250}.

GO - Biological processes (BP): condensed mesenchymal cell proliferation [GO:0072137]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nephron development [GO:0072006]

GO - Molecular function (MF): calcium ion binding [GO:0005509]

GO - Cellular component (CC): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R758C	DO220912	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.8301
p.R119H	DO230311	COCA	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.8244
p.R119H	DO41584	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.8244
p.S888F	DO222411	MELA	ICGC	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.7982
p.G116W	TCGA-DK-AA6U	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7825
p.D757A	TCGA-DM-A1HB	COAD	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7793
p.S884L	TCGA-66-2785	LUSC	TCGA	FLVYED	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.7667
p.S240L	TCGA-EO-A3B0	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7667
p.S240L	ACH-001842	Bile Duct Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7667
p.I118M	ACH-000813	Lung Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7618
p.G758C	TCGA-EE-A29Q	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.76
p.G758C	DO37866	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.76
p.A761S	DO228844	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7588
p.G764R	DO222775	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7568
p.G764V	TCGA-BF-A1PZ	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7532
p.G764V	DO50279	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	757:765	Mutation altering degron motif	0.7532
p.F280I	DO33624	PACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7415
p.Q1757R	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVNS	DEG_SCF_TRCP1_1	1752:1757	Mutation altering degron motif	0.7329
p.D169Y	TCGA-AX-A0J1	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.7325
p.K278T	TCGA-CA-6717	COAD	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7306

Showing 1 to 20 of 267 entries

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No resistance data available for this Degron.

Kaplan plot for DCHS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCHS2

UniProt ID: Q6V1P9

Entrez ID: 54798

Protein name: Protocadherin-23 (Cadherin-27) (Cadherin-like protein CDHJ) (Cadherin-like protein VR8) (Protein dachsous homolog 2) (Protocadherin PCDHJ)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for DCHS2 in