DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_SPOP_SBC_1

Location: 959:963

E3 ligase: SPOP

DEGRON score: 0.7895

ASA_SCORE: 35.68

COIL: 0.1212

CONS_SCORE: 0.4255

DSS_SCORE: 0.3226

HELIX: 0.0046

FCONS_SCORE: 1.5123

RIG_SCORE: 0.7208

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L961F	ACH-002365	Non-Cancerous	CCLE	ACSST	DEG_SPOP_SBC_1	0.6981
p.K965N	TCGA-4Z-AA7M	BLCA	TCGA	ACSST	DEG_SPOP_SBC_1	0.2778
p.K965N	DO218976	BLCA	ICGC	ACSST	DEG_SPOP_SBC_1	0.2778
p.K965T	TCGA-EY-A1G8	UCEC	TCGA	ACSST	DEG_SPOP_SBC_1	0.2778
p.K965T	DO43578	UCEC	ICGC	ACSST	DEG_SPOP_SBC_1	0.2778
p.A957T	DO51055	PRAD	ICGC	ACSST	DEG_SPOP_SBC_1	0.2778
p.N966K	DO229036	LICA	ICGC	ACSST	DEG_SPOP_SBC_1	0.25
p.I967T	DO7962	COAD	ICGC	ACSST	DEG_SPOP_SBC_1	0.2222
p.G955D	DO38551	STAD	ICGC	ACSST	DEG_SPOP_SBC_1	0.2222
p.G955S	DO47865	STAD	ICGC	ACSST	DEG_SPOP_SBC_1	0.2222
p.T968A	DO229392	PRAD	ICGC	ACSST	DEG_SPOP_SBC_1	0.1944
p.H954Q	DO229216	THCA	ICGC	ACSST	DEG_SPOP_SBC_1	0.1944
p.R953I	DO50743	LICA	ICGC	ACSST	DEG_SPOP_SBC_1	0.1667
p.I952T	DO224975	BRCA	ICGC	ACSST	DEG_SPOP_SBC_1	0.1389
p.M970T	SIDM00783	Colorectal Carcinoma	GDSC	ACSST	DEG_SPOP_SBC_1	0.1389
p.M970T	HCT-116	large_intestine	COSMIC	ACSST	DEG_SPOP_SBC_1	0.1389
p.D971N	SIDM00282	Colorectal Carcinoma	GDSC	ACSST	DEG_SPOP_SBC_1	0.1111
p.D971N	CW-2	large_intestine	COSMIC	ACSST	DEG_SPOP_SBC_1	0.1111
p.S972L	TCGA-D9-A6EC	SKCM	TCGA	ACSST	DEG_SPOP_SBC_1	0.0833
p.S972L	DO50291	SKCM	ICGC	ACSST	DEG_SPOP_SBC_1	0.0833
p.Q950E	TCGA-SY-A9G5	BLCA	TCGA	ACSST	DEG_SPOP_SBC_1	0.0833
p.Q950E	DO51906	BLCA	ICGC	ACSST	DEG_SPOP_SBC_1	0.0833
p.S949Y	TCGA-B5-A0JY	UCEC	TCGA	ACSST	DEG_SPOP_SBC_1	0.0556
p.S949Y	TCGA-EO-A22X	UCEC	TCGA	ACSST	DEG_SPOP_SBC_1	0.0556
p.S949Y	DO43041	UCEC	ICGC	ACSST	DEG_SPOP_SBC_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	DEG_SPOP_SBC_1	959:963	ACSST	SPOP	0.7895	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons