DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_SCF_FBW7_1

Location: 3324:3329

E3 ligase: FBXW7

DEGRON score: 0.9829

ASA_SCORE: 57.0167

COIL: 0.9133

CONS_SCORE: 0

DSS_SCORE: 0.4318

HELIX: 0.0235

FCONS_SCORE: 0

RIG_SCORE: 0.642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3336M	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	0.1389
p.F3328L	SIDM01611	Endometrial Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	0.587
p.P3330L	SIDM01413	Oral Cavity Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	0.3056
p.P3330S	SIDM01413	Oral Cavity Carcinoma	GDSC	MTPNFS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	DEG_SCF_FBW7_1	3324:3329	MTPNFS	FBXW7	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons