DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_APCC_DBOX_1

Location: 165:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6988

ASA_SCORE: 59.7556

COIL: 0.5058

CONS_SCORE: 0.4047

DSS_SCORE: 0.3801

HELIX: 0.0121

FCONS_SCORE: 0.9647

RIG_SCORE: 0.768

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D169Y	TCGA-AX-A0J1	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.7325
p.N161H	TCGA-AZ-4315	COAD	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.2222
p.E178K	TCGA-B5-A1MR	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1944
p.H174Y	TCGA-BF-A5ES	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.3056
p.P168S	TCGA-DF-A2KU	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5641
p.P179S	TCGA-EE-A29D	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1667
p.E168D	TCGA-EE-A29X	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6758
p.V183G	DO229003	COCA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.V183G	DO230529	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.V183G	DO230535	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.V183G	DO230990	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.V183G	DO231075	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.V183G	DO231049	LUSC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.P174L	DO233791	GACA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.3056
p.D155E	DO229029	LICA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0556
p.P161L	DO232761	PBCA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.2222
p.P158S	DO38404	STAD	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1389
p.P161S	DO223286	UCEC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.2222
p.E171K	DO41758	UCEC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.7022
p.T181I	SIDM01949	Esophageal Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1111
p.S171F	SIDM01175	Other Sarcomas	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6871
p.S171F	ACH-002309	Sarcoma	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6871
p.S171F	SW684	soft_tissue	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6871
p.V176I	SIDM01169	Ovarian Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.25
p.V176I	TOV-21G	ovary	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.25
p.D170E	SIDM00264	Ewing's Sarcoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5647
p.D170E	ACH-002105	Bone Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5647
p.D170E	ES4	bone	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5647
p.P182S	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0833
p.P182S	ACH-000353	Esophageal Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0833
p.P182S	TE-15	oesophagus	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0833
p.P181L	ACH-000670	Lung Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1111
p.P179L	ACH-000968	Skin Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1667
p.L174F	ACH-001861	Gallbladder Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRFPLDSLQ

Degron related mutations and impact score

Drug responses associated with DCHS2 mutations

All proteins holding degron of PRFPLDSLQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	DEG_APCC_DBOX_1	165:173	PRFPLDSLQ	APC,CDC20,FZR1	0.6988	More...