DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_APCC_DBOX_1

Location: 165:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6988

ASA_SCORE: 59.7556

COIL: 0.5058

CONS_SCORE: 0.4047

DSS_SCORE: 0.3801

HELIX: 0.0121

FCONS_SCORE: 0.9647

RIG_SCORE: 0.768

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D169Y	TCGA-AX-A0J1	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.7325
p.E171K	DO41758	UCEC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.7022
p.S171F	SIDM01175	Other Sarcomas	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6871
p.S171F	ACH-002309	Sarcoma	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6871
p.S171F	SW684	soft_tissue	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6871
p.E168D	TCGA-EE-A29X	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.6758
p.D170E	SIDM00264	Ewing's Sarcoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5647
p.D170E	ACH-002105	Bone Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5647
p.D170E	ES4	bone	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5647
p.P168S	TCGA-DF-A2KU	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.5641
p.H174Y	TCGA-BF-A5ES	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.3056
p.P174L	DO233791	GACA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.3056
p.L174F	ACH-001861	Gallbladder Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.3056
p.V176I	SIDM01169	Ovarian Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.25
p.V176I	TOV-21G	ovary	COSMIC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.25
p.N161H	TCGA-AZ-4315	COAD	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.2222
p.P161L	DO232761	PBCA	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.2222
p.P161S	DO223286	UCEC	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.2222
p.E178K	TCGA-B5-A1MR	UCEC	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1944
p.P179S	TCGA-EE-A29D	SKCM	TCGA	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1667
p.P179L	ACH-000968	Skin Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1667
p.P158S	DO38404	STAD	ICGC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1389
p.T181I	SIDM01949	Esophageal Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1111
p.P181L	ACH-000670	Lung Cancer	CCLE	PRFPLDSLQ	DEG_APCC_DBOX_1	0.1111
p.P182S	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PRFPLDSLQ	DEG_APCC_DBOX_1	0.0833

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Drug responses associated with DCHS2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRFPLDSLQ

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	DEG_APCC_DBOX_1	165:173	PRFPLDSLQ	APC,CDC20,FZR1	0.6988	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRFPLDSLQ

Degron related mutations and impact score

Drug responses associated with DCHS2 mutations

All proteins holding degron of PRFPLDSLQ