DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_APCC_DBOX_1

Location: 275:283

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6312

ASA_SCORE: 50.3444

COIL: 0.1502

CONS_SCORE: 0.1322

DSS_SCORE: 0.3288

HELIX: 0.0023

FCONS_SCORE: 1.0043

RIG_SCORE: 0.7504

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F280I	DO33624	PACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.7415
p.K278T	TCGA-CA-6717	COAD	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.7306
p.K278T	DO8264	COAD	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.7306
p.A276V	TCGA-A5-A0G1	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.6936
p.A276V	DO42472	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.6936
p.G272S	TCGA-EY-A1GF	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.25
p.F287L	TCGA-A5-A2K5	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.2222
p.F287L	DO41379	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.2222
p.M288I	TCGA-BS-A0UF	UCEC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.1944
p.M288I	DO41488	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.1944
p.R269H	DO233652	GACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.1667
p.K291E	TCGA-MI-A75H	LIHC	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.1111
p.K291E	DO49710	LIHC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.1111
p.K267M	TCGA-ZF-A9RM	BLCA	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.1111
p.K267M	DO219079	BLCA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.1111
p.E267K	ACH-001134	Lymphoma	CCLE	RRTGLLSVE	DEG_APCC_DBOX_1	0.1111
p.F266L	DO229019	LICA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.0833
p.H265P	TCGA-05-4418	LUAD	TCGA	RRTGLLSVE	DEG_APCC_DBOX_1	0.0556
p.H265P	DO23814	LUAD	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.0556
p.E293K	DO233254	GACA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.0556
p.E293K	DO230449	UTCA	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.0556
p.G265S	DO41704	UCEC	ICGC	RRTGLLSVE	DEG_APCC_DBOX_1	0.0556
p.H265Y	ACH-000650	Skin Cancer	CCLE	RRTGLLSVE	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	DEG_APCC_DBOX_1	275:283	RRTGLLSVE	APC,CDC20,FZR1	0.6312	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons