DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: LIG_APCC_ABBA_1

Location: 116:121

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5435

ASA_SCORE: 45.9

COIL: 0.478

CONS_SCORE: 0.3624

DSS_SCORE: 0.3826

HELIX: 0.0122

FCONS_SCORE: 1.1708

RIG_SCORE: 0.7679

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R128S	TCGA-77-A5G8	LUSC	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1389
p.R129W	TCGA-A6-2686	COAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1111
p.R129W	TCGA-EO-A22U	UCEC	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1111
p.R129W	TCGA-G4-6628	COAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1111
p.R126H	TCGA-AJ-A3EK	UCEC	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.D112N	TCGA-BR-8680	STAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.2222
p.D112N	TCGA-EO-A22X	UCEC	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.2222
p.D112N	ACH-002096	Skin Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	0.2222
p.G116W	TCGA-DK-AA6U	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.7825
p.D115E	TCGA-DK-AA6U	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.3056
p.R110W	TCGA-E9-A1RE	BRCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1667
p.R110Q	TCGA-HC-A6HY	PRAD	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1667
p.R126K	TCGA-LN-A49S	ESCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.V120F	TCGA-ZF-A9R1	BLCA	TCGA	FHVHPD	LIG_APCC_ABBA_1	0.7068
p.R122W	DO10132	COAD	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.3056
p.R122W	DO7828	COAD	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.3056
p.R122W	DO8658	COAD	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.3056
p.R122W	DO43755	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.3056
p.R119H	DO230311	COCA	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.8244
p.R119H	DO41584	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.8244
p.R126C	DO228542	GACA	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.V111M	DO233088	GACA	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.R123C	DO233885	GACA	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.2778
p.R128W	DO219537	LIHC	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.1389
p.I117T	DO231636	LINC	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.7078
p.R129Q	DO43041	UCEC	ICGC	FHVHPD	LIG_APCC_ABBA_1	0.1111
p.P111L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.P111L	ACH-000960	Leukemia	CCLE	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.P111L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.S107Y	SIDM00329	Hodgkin's Lymphoma	GDSC	FHVHPD	LIG_APCC_ABBA_1	0.0833
p.S107Y	ACH-000806	Lymphoma	CCLE	FHVHPD	LIG_APCC_ABBA_1	0.0833
p.S107Y	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	FHVHPD	LIG_APCC_ABBA_1	0.0833
p.P111Q	SIDM01641	Non-Cancerous	GDSC	FHVHPD	LIG_APCC_ABBA_1	0.1944
p.I118M	ACH-000813	Lung Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	0.7618
p.D125Y	ACH-000938	Leukemia	CCLE	FHVHPD	LIG_APCC_ABBA_1	0.2222
p.A131T	ACH-000996	Endometrial/Uterine Cancer	CCLE	FHVHPD	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FHVHPD

Degron related mutations and impact score

Drug responses associated with DCHS2 mutations

All proteins holding degron of FHVHPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	LIG_APCC_ABBA_1	116:121	FHVHPD	APC,CDC20,FZR1	0.5435	More...