DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: LIG_APCC_ABBA_1

Location: 883:888

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8104

ASA_SCORE: 49.65

COIL: 0.3237

CONS_SCORE: 0.2594

DSS_SCORE: 0.3227

HELIX: 0.0083

FCONS_SCORE: 0.5217

RIG_SCORE: 0.8677

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V878F	TCGA-44-3918	LUAD	TCGA	FLVYED	LIG_APCC_ABBA_1	0.1944
p.S884L	TCGA-66-2785	LUSC	TCGA	FLVYED	LIG_APCC_ABBA_1	0.7667
p.A895T	TCGA-AA-A010	COAD	TCGA	FLVYED	LIG_APCC_ABBA_1	0.1389
p.A895T	DO222492	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.1389
p.K892N	TCGA-BR-8368	STAD	TCGA	FLVYED	LIG_APCC_ABBA_1	0.2222
p.K892N	DO47981	STAD	ICGC	FLVYED	LIG_APCC_ABBA_1	0.2222
p.V878A	TCGA-EE-A29M	SKCM	TCGA	FLVYED	LIG_APCC_ABBA_1	0.1944
p.D894Y	TCGA-GU-A767	BLCA	TCGA	FLVYED	LIG_APCC_ABBA_1	0.1667
p.D894Y	DO51892	BLCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.1667
p.K892Q	TCGA-UY-A78K	BLCA	TCGA	FLVYED	LIG_APCC_ABBA_1	0.2222
p.K892Q	DO219031	BLCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.2222
p.K892T	TCGA-V5-A7RB	ESCA	TCGA	FLVYED	LIG_APCC_ABBA_1	0.2222
p.L884I	DO44077	BLCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.6063
p.N897S	DO229010	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.0833
p.N897S	DO229013	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.0833
p.N897S	DO229016	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.0833
p.N897S	DO229003	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.0833
p.N897S	DO229005	COCA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.0833
p.E887D	DO234330	ESAD	ICGC	FLVYED	LIG_APCC_ABBA_1	0.5647
p.H890Q	DO228976	LICA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.2778
p.P873H	DO24900	LUAD	ICGC	FLVYED	LIG_APCC_ABBA_1	0.0556
p.S888F	DO222411	MELA	ICGC	FLVYED	LIG_APCC_ABBA_1	0.7982
p.F876C	DO50076	UCEC	ICGC	FLVYED	LIG_APCC_ABBA_1	0.1389
p.I895T	SIDM00570	Gastric Carcinoma	GDSC	FLVYED	LIG_APCC_ABBA_1	0.1389
p.I895T	NUGC-4	stomach	COSMIC	FLVYED	LIG_APCC_ABBA_1	0.1389
p.P894L	SIDM00537	Colorectal Carcinoma	GDSC	FLVYED	LIG_APCC_ABBA_1	0.1667
p.P894L	GP5d	large_intestine	COSMIC	FLVYED	LIG_APCC_ABBA_1	0.1667
p.E877K	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	FLVYED	LIG_APCC_ABBA_1	0.1667
p.S887G	ACH-000984	Endometrial/Uterine Cancer	CCLE	FLVYED	LIG_APCC_ABBA_1	0.6993
p.K892R	ACH-001417	Lung Cancer	CCLE	FLVYED	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FLVYED

Degron related mutations and impact score

Drug responses associated with DCHS2 mutations

All proteins holding degron of FLVYED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	LIG_APCC_ABBA_1	883:888	FLVYED	APC,CDC20,FZR1	0.8104	More...