DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_SCF_TRCP1_1

Location: 1752:1757

E3 ligase: BTRC

DEGRON score: 0.5913

ASA_SCORE: 57.2333

COIL: 0.8017

CONS_SCORE: 0.2806

DSS_SCORE: 0.314

HELIX: 0.0558

FCONS_SCORE: 0.7588

RIG_SCORE: 0.7337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1750I	TCGA-06-5416	GBM	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.2778
p.F1750I	DO10880	GBM	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.2778
p.L1748I	TCGA-17-Z001	LUAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.2222
p.L1748P	TCGA-17-Z031	LUAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.2222
p.L1761F	TCGA-38-4629	LUAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.2222
p.L1761F	DO23771	LUAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.2222
p.V1760I	TCGA-VQ-A8P2	STAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.V1760I	TCGA-WS-AB45	COAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.V1760I	DO51734	COAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.V1760I	DO51761	STAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.S1764R	TCGA-VQ-A91V	STAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.1389
p.S1764R	DO222356	STAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1389
p.K1746T	TCGA-VQ-A925	STAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.K1746T	DO234462	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.K1746T	DO233736	GACA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.K1746T	DO51796	STAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.D1749H	TCGA-VR-A8EX	ESCA	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.K1746R	DO50452	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.K1746R	DO234453	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.K1746R	DO228305	MALY	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.K1746M	DO234204	ESAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.E1763D	DO233124	GACA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1667
p.E1744V	DO50835	LICA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1111
p.Q1760R	SIDM01451	Pancreatic Carcinoma	GDSC	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.Q1757R	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVNS	DEG_SCF_TRCP1_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons