DegronMD - Q96JQ0(DCHS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G211V	TCGA-38-4625	LUAD	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.1944
p.G211V	DO23952	LUAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.1944
p.G995W	TCGA-49-AARE	LUAD	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.3056
p.G995W	DO218922	LUAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.3056
p.P1003T	TCGA-75-6214	LUAD	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.5919
p.P1003T	DO24830	LUAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.5919
p.R2078L	TCGA-85-8071	LUSC	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.R2078L	DO26755	LUSC	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.A2075S	TCGA-97-7554	LUAD	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.1389
p.A2075S	DO23592	LUAD	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.1389
p.R928Q	TCGA-A5-A1OF	UCEC	TCGA	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation rewiring degron network	0.3056
p.R928Q	DO42568	UCEC	ICGC	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation rewiring degron network	0.3056
p.P2086L	TCGA-AX-A2HA	UCEC	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.7582
p.P2086L	DO42504	UCEC	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.7582
p.R999Q	TCGA-AX-A2HC	UCEC	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	DO41572	UCEC	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	SIDM00801	Melanoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	SIDM01650	Non-Cancerous	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	SIDM00540	Oral Cavity Carcinoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	SIDM01228	Melanoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.R999Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6218
p.G198D	TCGA-AX-A2HC	UCEC	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.G198D	DO41572	UCEC	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.G198S	TCGA-AX-A2HD	UCEC	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.G198S	DO42608	UCEC	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.G198S	SIDM00217	Colorectal Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.G198S	ACH-000999	Colon/Colorectal Cancer	CCLE	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.G198S	SNU-1040	large intestine	COSMIC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.3056
p.V208A	TCGA-CG-5721	STAD	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.2778
p.V208A	DO38192	STAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.2778
p.R917Q	TCGA-CM-4743	COAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation rewiring degron network	0.1944
p.R917Q	DO8103	COAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation rewiring degron network	0.1944
p.A2769V	TCGA-CM-6162	COAD	TCGA	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.25
p.A2769V	DO8479	COAD	ICGC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.25
p.R2403W	TCGA-CV-7415	HNSC	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.0556
p.R2403W	DO14926	HNSC	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.0556
p.R2403W	SIDM01087	Melanoma	GDSC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.0556
p.R2403W	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.0556
p.R2403W	RPMI-7951	skin	COSMIC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.0556
p.R2403W	NCI-H1755	lung	COSMIC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.0556
p.V2398I	TCGA-D1-A103	UCEC	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.1944
p.V2398I	TCGA-EY-A549	UCEC	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.1944
p.V2398I	DO48174	UCEC	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.1944
p.V2398I	DO42312	UCEC	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.1944
p.R196H	TCGA-D1-A1O7	UCEC	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.25
p.R196H	DO41139	UCEC	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.25
p.A2394V	TCGA-D7-6527	STAD	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.3056
p.A2394V	DO38635	STAD	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.3056
p.P197S	TCGA-EE-A17X	SKCM	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.2778
p.P197S	DO37931	SKCM	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.2778
p.A2092T	TCGA-F5-6814	READ	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.25
p.A2092T	DO36556	READ	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.25
p.R196C	TCGA-HU-A4H4	STAD	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.25
p.R196C	DO47721	STAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.25
p.R994H	TCGA-VQ-A91K	STAD	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.2778
p.R994H	DO51785	STAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.2778
p.V925I	DO224713	BRCA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation altering degron motif	0.5965
p.E216K	DO224732	BRCA	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.0556
p.P203L	DO230309	COCA	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.7582
p.N1001S	DO50393	ESAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.5958
p.M2384K	DO234437	ESAD	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.2778
p.L2760P	DO233918	GACA	ICGC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.3056
p.S2073C	DO228313	LICA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.0833
p.R2768S	DO228978	LICA	ICGC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.2778
p.R1006S	DO229022	LICA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.6316
p.D1008E	DO229031	LICA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.5647
p.A997S	DO229052	LICA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.7588
p.L996Q	DO27104	LUSC	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.7765
p.P205L	DO220890	MELA	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.6471
p.L919F	DO222434	MELA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation rewiring degron network	0.25
p.R2078C	DO222880	MELA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.R2078C	DO228138	PBCA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.R2078H	DO34328	PACA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.R2078H	DO228450	PRAD	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.R1006H	DO35154	PACA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.7133
p.E216D	DO50416	PRAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.0556
p.R2768C	DO41199	UCEC	ICGC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.2778
p.R917W	SIDM01307	Colorectal Carcinoma	GDSC	DSGVNS	DEG_SCF_TRCP1_1	922:927	Mutation rewiring degron network	0.1944
p.A2081V	SIDM00434	Plasma Cell Myeloma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00267	Biliary Tract Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00533	Pancreatic Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00383	Gastric Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00579	Neuroblastoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM00273	Glioblastoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SIDM01587	Bladder Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	NB(TU)1-10	autonomic ganglia	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	TGBC24TKB	biliary tract	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	GI-1	central nervous system	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	TE-6	oesophagus	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	KYSE-510	oesophagus	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	SCH	stomach	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	TE-12	oesophagus	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A2081V	HuP-T3	pancreas	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.R2091T	SIDM00773	Non-Cancerous	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2778
p.R2091T	SIDM00656	Burkitt's Lymphoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2778
p.R2091T	SIDM00856	Other Solid Cancers	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2778
p.R2091T	SIDM00785	Acute Myeloid Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2778
p.R2091T	SIDM00641	Burkitt's Lymphoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2778
p.R2091T	SIDM01525	Acute Myeloid Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2778
p.V2398F	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LEHTPPGS	DEG_SCF_FBW7_1	2386:2393	Mutation rewiring degron network	0.1944
p.G211E	SIDM00352	Ovarian Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.1944
p.G211E	ACH-000719	Ovarian Cancer	CCLE	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.1944
p.G211E	RMG-I	ovary	COSMIC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation rewiring degron network	0.1944
p.D990Y	SIDM00789	Colorectal Carcinoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.1667
p.D990Y	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.1667
p.D990Y	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.1667
p.D990Y	HCT-15	large intestine	COSMIC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation rewiring degron network	0.1667
p.R2755H	SIDM00971	Breast Carcinoma	GDSC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.1667
p.P205A	SIDM00280	Gastric Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.6392
p.P205A	ACH-000560	Gastric Cancer	CCLE	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.6392
p.P205A	ECC10	stomach	COSMIC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.6392
p.P199R	SIDM00068	Colorectal Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.7512
p.P199R	SIDM01664	Prostate Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	199:206	Mutation altering degron motif	0.7512
p.R2770Q	SIDM00118	Colorectal Carcinoma	GDSC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.2222
p.R2770Q	ACH-001081	Colon/Colorectal Cancer	CCLE	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.2222
p.R2770Q	HCC2998	large intestine	COSMIC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.2222
p.A997D	ACH-000634	Brain Cancer	CCLE	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	996:1009	Mutation altering degron motif	0.7793
p.P2752T	KATOIII	stomach	COSMIC	NSSTGE	DEG_Kelch_Keap1_1	2761:2766	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCHS1

UniProt ID: Q96JQ0

Entrez ID: 8642

Protein name: Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCHS1 in