DegronMD

Uniprot ID: Q96JQ0

Source protein: Protocadherin-16

Source gene: DCHS1

Class: DEG_ODPH_VHL_1

Location: 996:1009

E3 ligase: VHL

DEGRON score: 0.8438

ASA_SCORE: 49.4357

COIL: 0.3935

CONS_SCORE: 0.5103

DSS_SCORE: 0.4766

HELIX: 0.004

FCONS_SCORE: 0.9575

RIG_SCORE: 0.7566

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G995W	TCGA-49-AARE	LUAD	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.3056
p.G995W	DO218922	LUAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.3056
p.P1003T	TCGA-75-6214	LUAD	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.5919
p.P1003T	DO24830	LUAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.5919
p.R999Q	TCGA-AX-A2HC	UCEC	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	DO41572	UCEC	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	SIDM00801	Melanoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	SIDM01650	Non-Cancerous	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	SIDM00540	Oral Cavity Carcinoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	SIDM01228	Melanoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R999Q	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6218
p.R994H	TCGA-VQ-A91K	STAD	TCGA	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.2778
p.R994H	DO51785	STAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.2778
p.N1001S	DO50393	ESAD	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.5958
p.R1006S	DO229022	LICA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.6316
p.D1008E	DO229031	LICA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.5647
p.A997S	DO229052	LICA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.7588
p.L996Q	DO27104	LUSC	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.7765
p.R1006H	DO35154	PACA	ICGC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.7133
p.D990Y	SIDM00789	Colorectal Carcinoma	GDSC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.1667
p.D990Y	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.1667
p.D990Y	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.1667
p.D990Y	HCT-15	large_intestine	COSMIC	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.1667
p.A997D	ACH-000634	Brain Cancer	CCLE	LAPRFNSPTYRVDL	DEG_ODPH_VHL_1	0.7793

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPRFNSPTYRVDL

Degron related mutations and impact score

Drug responses associated with DCHS1 mutations

All proteins holding degron of LAPRFNSPTYRVDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ0	Protocadherin-16	DEG_ODPH_VHL_1	996:1009	LAPRFNSPTYRVDL	VHL	0.8438	More...