DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NSSTGE
Uniprot ID:
Q96JQ0
Source protein:
Protocadherin-16
Source gene:
DCHS1
Class:
DEG_Kelch_Keap1_1
Location:
2761:2766
E3 ligase:
KEAP1
DEGRON score:
0.9688
ASA_SCORE:
50.1667
COIL:
0.787
CONS_SCORE:
0.5878
DSS_SCORE:
0.3538
HELIX:
0.0075
FCONS_SCORE:
1.227
RIG_SCORE:
0.7058
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L2760P
DO233918
GACA
ICGC
NSSTGE
DEG_Kelch_Keap1_1
0.3056
p.R2768S
DO228978
LICA
ICGC
NSSTGE
DEG_Kelch_Keap1_1
0.2778
p.R2768C
DO41199
UCEC
ICGC
NSSTGE
DEG_Kelch_Keap1_1
0.2778
p.A2769V
TCGA-CM-6162
COAD
TCGA
NSSTGE
DEG_Kelch_Keap1_1
0.25
p.A2769V
DO8479
COAD
ICGC
NSSTGE
DEG_Kelch_Keap1_1
0.25
p.R2770Q
SIDM00118
Colorectal Carcinoma
GDSC
NSSTGE
DEG_Kelch_Keap1_1
0.2222
p.R2770Q
ACH-001081
Colon/Colorectal Cancer
CCLE
NSSTGE
DEG_Kelch_Keap1_1
0.2222
p.R2770Q
HCC2998
large_intestine
COSMIC
NSSTGE
DEG_Kelch_Keap1_1
0.2222
p.R2755H
SIDM00971
Breast Carcinoma
GDSC
NSSTGE
DEG_Kelch_Keap1_1
0.1667
p.P2752T
KATOIII
stomach
COSMIC
NSSTGE
DEG_Kelch_Keap1_1
0.0833
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Drug responses associated with DCHS1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of NSSTGE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JQ0
Protocadherin-16
DEG_Kelch_Keap1_1
2761:2766
NSSTGE
KEAP1
0.9688
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