DegronMD

Uniprot ID: Q96JQ0

Source protein: Protocadherin-16

Source gene: DCHS1

Class: DEG_Kelch_Keap1_1

Location: 2761:2766

E3 ligase: KEAP1

DEGRON score: 0.9688

ASA_SCORE: 50.1667

COIL: 0.787

CONS_SCORE: 0.5878

DSS_SCORE: 0.3538

HELIX: 0.0075

FCONS_SCORE: 1.227

RIG_SCORE: 0.7058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2769V	TCGA-CM-6162	COAD	TCGA	NSSTGE	DEG_Kelch_Keap1_1	0.25
p.A2769V	DO8479	COAD	ICGC	NSSTGE	DEG_Kelch_Keap1_1	0.25
p.L2760P	DO233918	GACA	ICGC	NSSTGE	DEG_Kelch_Keap1_1	0.3056
p.R2768S	DO228978	LICA	ICGC	NSSTGE	DEG_Kelch_Keap1_1	0.2778
p.R2768C	DO41199	UCEC	ICGC	NSSTGE	DEG_Kelch_Keap1_1	0.2778
p.R2755H	SIDM00971	Breast Carcinoma	GDSC	NSSTGE	DEG_Kelch_Keap1_1	0.1667
p.R2770Q	SIDM00118	Colorectal Carcinoma	GDSC	NSSTGE	DEG_Kelch_Keap1_1	0.2222
p.R2770Q	ACH-001081	Colon/Colorectal Cancer	CCLE	NSSTGE	DEG_Kelch_Keap1_1	0.2222
p.R2770Q	HCC2998	large_intestine	COSMIC	NSSTGE	DEG_Kelch_Keap1_1	0.2222
p.P2752T	KATOIII	stomach	COSMIC	NSSTGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ0	Protocadherin-16	DEG_Kelch_Keap1_1	2761:2766	NSSTGE	KEAP1	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons