DegronMD

Uniprot ID: Q96JQ0

Source protein: Protocadherin-16

Source gene: DCHS1

Class: DEG_SCF_TRCP1_1

Location: 922:927

E3 ligase: BTRC

DEGRON score: 0.946

ASA_SCORE: 54.65

COIL: 0.8592

CONS_SCORE: 0.5318

DSS_SCORE: 0.2814

HELIX: 0.043

FCONS_SCORE: 1.0066

RIG_SCORE: 0.7297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R928Q	TCGA-A5-A1OF	UCEC	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.3056
p.R928Q	DO42568	UCEC	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.3056
p.R917Q	TCGA-CM-4743	COAD	TCGA	DSGVNS	DEG_SCF_TRCP1_1	0.1944
p.R917Q	DO8103	COAD	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.1944
p.V925I	DO224713	BRCA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.5965
p.L919F	DO222434	MELA	ICGC	DSGVNS	DEG_SCF_TRCP1_1	0.25
p.R917W	SIDM01307	Colorectal Carcinoma	GDSC	DSGVNS	DEG_SCF_TRCP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons