DegronMD

Uniprot ID: Q96JQ0

Source protein: Protocadherin-16

Source gene: DCHS1

Class: DEG_SCF_FBW7_2

Location: 199:206

E3 ligase: FBXW7

DEGRON score: 0.935

ASA_SCORE: 62.4125

COIL: 0.7294

CONS_SCORE: 0.2525

DSS_SCORE: 0.6595

HELIX: 0.0201

FCONS_SCORE: 0.9181

RIG_SCORE: 0.6617

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G211V	TCGA-38-4625	LUAD	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.1944
p.G211V	DO23952	LUAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.1944
p.G198D	TCGA-AX-A2HC	UCEC	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.G198D	DO41572	UCEC	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.G198S	TCGA-AX-A2HD	UCEC	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.G198S	DO42608	UCEC	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.G198S	SIDM00217	Colorectal Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.G198S	ACH-000999	Colon/Colorectal Cancer	CCLE	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.G198S	SNU-1040	large_intestine	COSMIC	PDGTPVPE	DEG_SCF_FBW7_2	0.3056
p.V208A	TCGA-CG-5721	STAD	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.2778
p.V208A	DO38192	STAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.2778
p.R196H	TCGA-D1-A1O7	UCEC	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.25
p.R196H	DO41139	UCEC	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.25
p.P197S	TCGA-EE-A17X	SKCM	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.2778
p.P197S	DO37931	SKCM	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.2778
p.R196C	TCGA-HU-A4H4	STAD	TCGA	PDGTPVPE	DEG_SCF_FBW7_2	0.25
p.R196C	DO47721	STAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.25
p.E216K	DO224732	BRCA	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.0556
p.P203L	DO230309	COCA	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.7582
p.P205L	DO220890	MELA	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.6471
p.E216D	DO50416	PRAD	ICGC	PDGTPVPE	DEG_SCF_FBW7_2	0.0556
p.G211E	SIDM00352	Ovarian Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	0.1944
p.G211E	ACH-000719	Ovarian Cancer	CCLE	PDGTPVPE	DEG_SCF_FBW7_2	0.1944
p.G211E	RMG-I	ovary	COSMIC	PDGTPVPE	DEG_SCF_FBW7_2	0.1944
p.P205A	SIDM00280	Gastric Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	0.6392
p.P205A	ACH-000560	Gastric Cancer	CCLE	PDGTPVPE	DEG_SCF_FBW7_2	0.6392
p.P205A	ECC10	stomach	COSMIC	PDGTPVPE	DEG_SCF_FBW7_2	0.6392
p.P199R	SIDM00068	Colorectal Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	0.7512
p.P199R	SIDM01664	Prostate Carcinoma	GDSC	PDGTPVPE	DEG_SCF_FBW7_2	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDGTPVPE

Degron related mutations and impact score

Drug responses associated with DCHS1 mutations

All proteins holding degron of PDGTPVPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ0	Protocadherin-16	DEG_SCF_FBW7_2	199:206	PDGTPVPE	FBXW7	0.935	More...