DegronMD

Uniprot ID: Q96JQ0

Source protein: Protocadherin-16

Source gene: DCHS1

Class: DEG_SCF_FBW7_1

Location: 2386:2393

E3 ligase: FBXW7

DEGRON score: 0.9779

ASA_SCORE: 62.7375

COIL: 0.8314

CONS_SCORE: 0.4451

DSS_SCORE: 0.2729

HELIX: 0.016

FCONS_SCORE: 1.0569

RIG_SCORE: 0.7255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2403W	TCGA-CV-7415	HNSC	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	0.0556
p.R2403W	DO14926	HNSC	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	0.0556
p.R2403W	SIDM01087	Melanoma	GDSC	LEHTPPGS	DEG_SCF_FBW7_1	0.0556
p.R2403W	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	LEHTPPGS	DEG_SCF_FBW7_1	0.0556
p.R2403W	RPMI-7951	skin	COSMIC	LEHTPPGS	DEG_SCF_FBW7_1	0.0556
p.R2403W	NCI-H1755	lung	COSMIC	LEHTPPGS	DEG_SCF_FBW7_1	0.0556
p.V2398I	TCGA-D1-A103	UCEC	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	0.1944
p.V2398I	TCGA-EY-A549	UCEC	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	0.1944
p.V2398I	DO48174	UCEC	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	0.1944
p.V2398I	DO42312	UCEC	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	0.1944
p.A2394V	TCGA-D7-6527	STAD	TCGA	LEHTPPGS	DEG_SCF_FBW7_1	0.3056
p.A2394V	DO38635	STAD	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	0.3056
p.M2384K	DO234437	ESAD	ICGC	LEHTPPGS	DEG_SCF_FBW7_1	0.2778
p.V2398F	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LEHTPPGS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ0	Protocadherin-16	DEG_SCF_FBW7_1	2386:2393	LEHTPPGS	FBXW7	0.9779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons