DegronMD

Uniprot ID: Q96JQ0

Source protein: Protocadherin-16

Source gene: DCHS1

Class: DEG_SCF_FBW7_1

Location: 2082:2089

E3 ligase: FBXW7

DEGRON score: 0.7909

ASA_SCORE: 46.2

COIL: 0.4969

CONS_SCORE: 0.5125

DSS_SCORE: 0.6119

HELIX: 0.0019

FCONS_SCORE: 1.0567

RIG_SCORE: 0.641

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2078L	TCGA-85-8071	LUSC	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	0.2222
p.R2078L	DO26755	LUSC	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.2222
p.A2075S	TCGA-97-7554	LUAD	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	0.1389
p.A2075S	DO23592	LUAD	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.1389
p.P2086L	TCGA-AX-A2HA	UCEC	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	0.7582
p.P2086L	DO42504	UCEC	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.7582
p.A2092T	TCGA-F5-6814	READ	TCGA	PPGTPIVS	DEG_SCF_FBW7_1	0.25
p.A2092T	DO36556	READ	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.25
p.S2073C	DO228313	LICA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.0833
p.R2078C	DO222880	MELA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.2222
p.R2078C	DO228138	PBCA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.2222
p.R2078H	DO34328	PACA	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.2222
p.R2078H	DO228450	PRAD	ICGC	PPGTPIVS	DEG_SCF_FBW7_1	0.2222
p.A2081V	SIDM00434	Plasma Cell Myeloma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00267	Biliary Tract Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00533	Pancreatic Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00383	Gastric Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00579	Neuroblastoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM00273	Glioblastoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SIDM01587	Bladder Carcinoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	NB(TU)1-10	autonomic_ganglia	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	TGBC24TKB	biliary_tract	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	GI-1	central_nervous_system	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	TE-6	oesophagus	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	KYSE-510	oesophagus	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	SCH	stomach	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	TE-12	oesophagus	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.A2081V	HuP-T3	pancreas	COSMIC	PPGTPIVS	DEG_SCF_FBW7_1	0.3056
p.R2091T	SIDM00773	Non-Cancerous	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.2778
p.R2091T	SIDM00656	Burkitt's Lymphoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.2778
p.R2091T	SIDM00856	Other Solid Cancers	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.2778
p.R2091T	SIDM00785	Acute Myeloid Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.2778
p.R2091T	SIDM00641	Burkitt's Lymphoma	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.2778
p.R2091T	SIDM01525	Acute Myeloid Leukemia	GDSC	PPGTPIVS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGTPIVS

Degron related mutations and impact score

Drug responses associated with DCHS1 mutations

All proteins holding degron of PPGTPIVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ0	Protocadherin-16	DEG_SCF_FBW7_1	2082:2089	PPGTPIVS	FBXW7	0.7909	More...