DegronMD

Uniprot ID: Q6V1P9

Source protein: Protocadherin-23

Source gene: DCHS2

Class: DEG_APCC_DBOX_1

Location: 757:765

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6025

ASA_SCORE: 44.2

COIL: 0.2218

CONS_SCORE: 0.1529

DSS_SCORE: 0.3743

HELIX: 0.0058

FCONS_SCORE: 0.9382

RIG_SCORE: 0.8181

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G764V	TCGA-BF-A1PZ	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	0.7532
p.G764V	DO50279	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.7532
p.L774H	TCGA-CG-4469	STAD	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	0.0833
p.L774H	DO38507	STAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0833
p.D757A	TCGA-DM-A1HB	COAD	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	0.7793
p.G758C	TCGA-EE-A29Q	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	0.76
p.G758C	DO37866	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.76
p.W755L	TCGA-EE-A2GK	SKCM	TCGA	VRVDLEDVN	DEG_APCC_DBOX_1	0.2778
p.W755L	DO37738	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.2778
p.V764M	DO230347	COCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.6097
p.V764M	DO234185	ESAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.6097
p.H768R	DO229010	COCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.H768R	DO229003	COCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.H768R	DO230659	LAML	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.H768R	DO231140	LAML	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.H768R	DO230556	LUSC	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.G758D	DO234204	ESAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.7198
p.L774P	DO234269	ESAD	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0833
p.Y751N	DO228313	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.1667
p.A761S	DO228844	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.7588
p.H768N	DO229019	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.N772K	DO229015	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.1389
p.T775N	DO229036	LICA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0556
p.G749D	DO220862	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.1111
p.R758C	DO220912	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.8301
p.G764R	DO222775	MELA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.7568
p.E762D	DO37595	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.5647
p.D747N	DO51259	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0556
p.P773S	DO38123	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.1111
p.H768Y	DO219456	SKCM	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.25
p.A747T	DO229253	THCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0556
p.A756V	DO229213	THCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.3056
p.N765Y	DO229234	THCA	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.5948
p.D763Y	DO41199	UCEC	ICGC	VRVDLEDVN	DEG_APCC_DBOX_1	0.6214
p.G748W	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0833
p.G748W	NCI-H2023	lung	COSMIC	VRVDLEDVN	DEG_APCC_DBOX_1	0.0833
p.P773L	SIDM00140	Melanoma	GDSC	VRVDLEDVN	DEG_APCC_DBOX_1	0.1111
p.P773L	COLO-792	skin	COSMIC	VRVDLEDVN	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRVDLEDVN

Degron related mutations and impact score

Drug responses associated with DCHS2 mutations

All proteins holding degron of VRVDLEDVN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V1P9	Protocadherin-23	DEG_APCC_DBOX_1	757:765	VRVDLEDVN	APC,CDC20,FZR1	0.6025	More...