DegronMD - O95271(TNKS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S139T	TCGA-04-1649	OV	TCGA	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.6005
p.S139T	DO32467	OV	ICGC	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.6005
p.S139L	TCGA-04-1649	OV	TCGA	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7667
p.S139L	TCGA-DK-A3IN	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7667
p.S139L	DO455	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7667
p.S139L	DO32467	OV	ICGC	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7667
p.S134F	TCGA-A2-A0CR	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.S134F	TCGA-A2-A0CR	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.S134F	DO44163	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.S134F	DO44163	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.T43A	TCGA-B2-3923	KIRC	TCGA	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.0556
p.T43A	DO18889	KIRC	ICGC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.0556
p.D649N	TCGA-BT-A42B	BLCA	TCGA	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.2778
p.S132F	TCGA-CV-A6K2	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7982
p.S132F	DO52079	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7982
p.R646H	TCGA-D1-A163	UCEC	TCGA	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.1944
p.R646H	DO233782	GACA	ICGC	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.1944
p.R646H	DO41008	UCEC	ICGC	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.1944
p.A117D	TCGA-DM-A1HB	COAD	TCGA	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1667
p.R653Q	TCGA-F5-6814	READ	TCGA	DYR	CBL_MET	651:653	Mutation altering degron motif	0.7329
p.L53M	TCGA-HU-8602	STAD	TCGA	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.711
p.L53M	DO47829	STAD	ICGC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.711
p.S111L	TCGA-XF-AAN2	BLCA	TCGA	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation altering degron motif	0.7667
p.S111L	DO219052	BLCA	ICGC	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation altering degron motif	0.7667
p.P644L	DO233944	GACA	ICGC	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.1389
p.G70V	DO228925	LICA	ICGC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.1944
p.G70V	ACH-000458	Skin Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.1944
p.R646L	DO228974	LICA	ICGC	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.1944
p.G124C	DO228978	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.A114S	DO228985	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.25
p.A657S	DO229037	LICA	ICGC	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.2222
p.R60L	SIDM00648	Small Cell Lung Carcinoma	GDSC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.7316
p.R60L	ACH-002169	Lung Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.7316
p.R60L	NCI-H1304	lung	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.7316
p.P129S	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6752
p.P129S	ACH-000667	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6752
p.P129S	HCC-44	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6752
p.G68V	SIDM00120	Prostate Carcinoma	GDSC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.25
p.G68V	ACH-000979	Prostate Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.25
p.G68V	DU-145	prostate	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.25
p.G122S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.G122S	ACH-001853	Bile Duct Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.G122S	ACH-002264	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.G122S	KYSE-50	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.A117P	SIDM01133	Other Solid Cancers	GDSC	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1667
p.A117P	ACH-002177	Lung Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1667
p.A117P	NCI-H835	lung	COSMIC	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1667
p.V104E	SIDM01608	Endometrial Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.25
p.V104E	ACH-000990	Endometrial/Uterine Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.25
p.D662Y	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	651:653	Mutation rewiring degron network	0.0833
p.D59E	ACH-000070	Leukemia	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.6758
p.D59E	697	haematopoietic and lymphoid tissue	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.6758
p.I62V	ACH-000612	Lymphoma	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.7076
p.I73V	ACH-000867	Lung Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.1111
p.I73V	ChaGo-K-1	lung	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.1111
p.L64P	ACH-000985	Colon/Colorectal Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.7582
p.L64P	LS-411N	large intestine	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation altering degron motif	0.7582
p.R146Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.R146Q	HT-115	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.P48L	ACH-001524	Skin Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.1944
p.S47F	ACH-001853	Bile Duct Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	53:65	Mutation rewiring degron network	0.1667

Kaplan plot for TNKS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNKS

UniProt ID: O95271

Entrez ID: 8658

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNKS in