DegronMD

Uniprot ID: O95271

Source protein: Poly [ADP-ribose] polymerase tankyrase-1

Source gene: TNKS

Class: DEG_SPOP_SBC_1

Location: 129:133

E3 ligase: SPOP

DEGRON score: 0.9965

ASA_SCORE: 71.74

COIL: 0.8546

CONS_SCORE: 0.2076

DSS_SCORE: 0.6235

HELIX: 0.1042

FCONS_SCORE: 1.085

RIG_SCORE: 0.4173

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S134F	TCGA-A2-A0CR	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	0.3056
p.S134F	DO44163	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.3056
p.S132F	TCGA-CV-A6K2	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.7982
p.S132F	DO52079	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7982
p.G124C	DO228978	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1944
p.P129S	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.6752
p.P129S	ACH-000667	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.6752
p.P129S	HCC-44	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.6752
p.G122S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.G122S	ACH-001853	Bile Duct Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.1389
p.G122S	ACH-002264	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.1389
p.G122S	KYSE-50	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.1389

Drug responses associated with TNKS mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q1325H (No)	GDSC	XAV939	85.987
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	XAV939	70.6467
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	XAV939	291.17
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	MN-64	230.21
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	WIKI4	40.489
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	AZ6102	88.198
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	XAV939	31.9722
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	XAV939	198.58
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	MN-64	248.22
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	WIKI4	148.93
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	AZ6102	7.1508
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	XAV939	62.2554
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	WIKI4	12.557
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	AZ6102	63.59
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	XAV939	79.3525
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	WIKI4	24.51
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	AZ6102	34.542
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.H705R (No)	GDSC	XAV939	26.3351
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	XAV939	23.2978
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	XAV939	15.182
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	MN-64	29.879
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	WIKI4	9.4223
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	AZ6102	1.6334
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	XAV939	16.9117
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	XAV939	100.54
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	MN-64	64.865
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	WIKI4	34.912
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	AZ6102	7.9351
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	XAV939	54.1713
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	XAV939	660.46
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	MN-64	266.56
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	WIKI4	77.804
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	AZ6102	105.5
SIDM00550	ESCA\|oesophagus	p.G122S (Yes)	GDSC	XAV939	50.7815
SIDM00550	ESCA\|oesophagus	p.G122S (Yes)	GDSC	XAV939	77.275
SIDM00550	ESCA\|oesophagus	p.G122S (Yes)	GDSC	MN-64	140.69
SIDM00550	ESCA\|oesophagus	p.G122S (Yes)	GDSC	WIKI4	35.27
SIDM00550	ESCA\|oesophagus	p.G122S (Yes)	GDSC	AZ6102	9.8282
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	XAV939	31.6494
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	XAV939	92.715
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	MN-64	91.757
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	XAV939	28.1116
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	XAV939	247.6
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	MN-64	118.17
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	WIKI4	39.52
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	AZ6102	16.971
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	XAV939	45.6414
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	XAV939	31.094
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	MN-64	103.44
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	WIKI4	26.656
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	AZ6102	10.89
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	XAV939	251.4354
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	WIKI4	96.525
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	AZ6102	544.64
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	XAV939	13.7175
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	XAV939	32.643
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	MN-64	31.387
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	WIKI4	37.338
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	AZ6102	3.084
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	XAV939	43.9755
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	XAV939	84.099
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	MN-64	267.11
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	WIKI4	38.357
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	AZ6102	7.2998
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	XAV939	18.2292
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	XAV939	110.15
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	MN-64	201.25
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	WIKI4	25.204
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	AZ6102	9.7102
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	XAV939	22.0108
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	WIKI4	136.35
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	AZ6102	5.2125
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.S726L (No)	GDSC	XAV939	59.5866
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	XAV939	109.662
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	XAV939	119.18
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	MN-64	235.8
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	WIKI4	26.924
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	AZ6102	11.064
SIDM00303	OV\|ovary	p.S91I (No)	GDSC	XAV939	7.3161
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	XAV939	17.7995
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	XAV939	55.072
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	MN-64	97.883
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	WIKI4	32.948
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	AZ6102	5.8907
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	XAV939	33.12
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	XAV939	47.82
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	MN-64	139.06
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	WIKI4	23.719
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	AZ6102	13.248
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	MN-64	234.76
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	XAV939	9.9121
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	XAV939	40.346
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	MN-64	41.058
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	WIKI4	44.377
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	AZ6102	10.693
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	XAV939	30.058
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	XAV939	14.922
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	MN-64	41.348
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	WIKI4	64.865
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	AZ6102	6.1498
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	XAV939	127.0465
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	XAV939	72.076
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	MN-64	234.68
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	WIKI4	65.973
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	AZ6102	81.504
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	XAV939	32.0149
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	XAV939	197.08
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	MN-64	245.83
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	WIKI4	27.828
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	AZ6102	10.241
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	XAV939	33.488
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	XAV939	21.277
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	MN-64	39.347
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	WIKI4	40.521
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	AZ6102	24.862
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	AZ6102	9.804
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	AZ6102	9.804
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	AZ6102	9.804
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	XAV939	20.6881
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	WIKI4	43.494
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	AZ6102	12.367
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	XAV939	38.9965
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	XAV939	93.678
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	MN-64	81.255
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	WIKI4	44.17
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	AZ6102	9.9173
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	XAV939	18.5747
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	XAV939	48.075
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	MN-64	81.085
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	WIKI4	36.023
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	AZ6102	6.1789
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	XAV939	100.4499
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	XAV939	71.743
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	MN-64	270.02
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	WIKI4	41.636
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	AZ6102	5.0573
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.I310V (No)	GDSC	XAV939	27.5392
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.H1100L (No)	GDSC	XAV939	59.9957
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	XAV939	60.9642
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	XAV939	63.82
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	MN-64	79.419
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	XAV939	61.4203
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	XAV939	30.454
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	MN-64	168.26
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	WIKI4	49.78
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	AZ6102	10.625
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	XAV939	61.5614
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	XAV939	188.95
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	MN-64	172.11
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	XAV939	61.5614
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	XAV939	188.95
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	MN-64	172.11
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	XAV939	102.427
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	XAV939	169.39
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	MN-64	69.824
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	WIKI4	26.953
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	AZ6102	33.407
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	MN-64	234.76
SIDM00191	KIRC\|kidney	p.A920T (No)	GDSC	XAV939	19.8717
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	XAV939	34.6906
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	XAV939	55.059
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	MN-64	139.07
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	WIKI4	146.88
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	AZ6102	59.89
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	XAV939	19.908
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	XAV939	42.133
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	MN-64	86.954
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	WIKI4	21.708
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	AZ6102	6.0872
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	XAV939	2.9243
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	XAV939	273.2
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	MN-64	309.57
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	WIKI4	104.93
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	AZ6102	83.293
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	XAV939	10.7811
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	XAV939	75.35
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	MN-64	32.346
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	WIKI4	34.56
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	AZ6102	21.284
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	XAV939	9.766
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	XAV939	29.351
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	MN-64	58.577
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	WIKI4	4.6635
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	AZ6102	4.3586
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	XAV939	24.5716
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	XAV939	90.205
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	MN-64	191.54
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	WIKI4	72.138
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	AZ6102	11.373
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	XAV939	26.8047
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	XAV939	65.54
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	MN-64	166.58
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	WIKI4	46.604
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	AZ6102	7.6066
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	XAV939	44.3323
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	XAV939	33.569
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	MN-64	131.89
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	WIKI4	31.513
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	AZ6102	7.9393
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	XAV939	2.3655
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	XAV939	32.553
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	MN-64	82.765
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	WIKI4	38.808
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	AZ6102	3.3947
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	XAV939	22.71
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	XAV939	71.998
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	MN-64	83.323
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	WIKI4	13.255
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	AZ6102	3.1757
SIDM00648	SCLC\|lung_small_cell_carcinoma	p.R60L (No)	GDSC	XAV939	78.1745
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	XAV939	7.4473
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	XAV939	28.116
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	MN-64	52.715
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	WIKI4	26.041
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	AZ6102	8.0552
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	XAV939	71.1269
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	XAV939	153.76
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	MN-64	205.78
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	WIKI4	102.73
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	AZ6102	3.0687
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	XAV939	14.8095
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	XAV939	47.362
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	MN-64	35.537
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	WIKI4	16.865
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	XAV939	5.2245
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	XAV939	40.786
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	MN-64	73.469
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	WIKI4	28.482
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	AZ6102	8.7542
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	XAV939	8.1249
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	XAV939	39.379
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	MN-64	42.267
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	XAV939	110.2345
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	XAV939	122.62
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	MN-64	124.55
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	XAV939	26.3981
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	XAV939	83.192
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	MN-64	659.92
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	WIKI4	33.349
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	AZ6102	23.748

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MTQ0	Homeobox protein notochord	DEG_SPOP_SBC_1	232:236	PSSSS	SPOP	0.9058	More...
O15040	Tectonin beta-propeller repeat-containing protein 2	DEG_SPOP_SBC_1	763:767	PSSSS	SPOP	0.9823	More...
O15146	Muscle, skeletal receptor tyrosine-protein kinase	DEG_SPOP_SBC_1	479:483	PSSSS	SPOP	0.8323	More...
O15197	Ephrin type-B receptor 6	DEG_SPOP_SBC_1	165:169	PSSSS	SPOP	0.6462	More...
O15209	Zinc finger and BTB domain-containing protein 22	DEG_SPOP_SBC_1	430:434	PSSSS	SPOP	0.9122	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	841:845	PSSSS	SPOP	0.9975	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	39:43	PSSSS	SPOP	0.972	More...
O15524	Suppressor of cytokine signaling 1	DEG_SPOP_SBC_1	25:29	PSSSS	SPOP	0.9817	More...
O43298	Zinc finger and BTB domain-containing protein 43	DEG_SPOP_SBC_1	143:147	PSSSS	SPOP	0.9926	More...
O43426	Synaptojanin-1	DEG_SPOP_SBC_1	1032:1036	PSSSS	SPOP	0.9976	More...
O43900	Prickle planar cell polarity protein 3	DEG_SPOP_SBC_1	549:553	PSSSS	SPOP	0.9245	More...
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	1142:1146	PSSSS	SPOP	0.9881	More...
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	99:103	PSSSS	SPOP	0.9421	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1115:1119	PSSSS	SPOP	0.9486	More...
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SPOP_SBC_1	272:276	PSSSS	SPOP	0.9973	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1276:1280	PSSSS	SPOP	0.9293	More...
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	336:340	PSSSS	SPOP	0.9977	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	290:294	PSSSS	SPOP	0.9979	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	129:133	PSSSS	SPOP	0.9965	More...
O95716	Ras-related protein Rab-3D	DEG_SPOP_SBC_1	193:197	PSSSS	SPOP	0.7948	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1144:1148	PSSSS	SPOP	0.9971	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1872:1876	PSSSS	SPOP	0.9707	More...
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	231:235	PSSSS	SPOP	0.98	More...
P20393	Nuclear receptor subfamily 1 group D member 1	DEG_SPOP_SBC_1	81:85	PSSSS	SPOP	0.9588	More...
P22607	Fibroblast growth factor receptor 3	DEG_SPOP_SBC_1	778:782	PSSSS	SPOP	0.9964	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	832:836	PSSSS	SPOP	0.995	More...
P29120	Neuroendocrine convertase 1	DEG_SPOP_SBC_1	646:650	PSSSS	SPOP	0.8406	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_SPOP_SBC_1	1242:1246	PSSSS	SPOP	0.9873	More...
P30405	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	DEG_SPOP_SBC_1	37:41	PSSSS	SPOP	0.8163	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	679:683	PSSSS	SPOP	0.9979	More...
P38432	Coilin	DEG_SPOP_SBC_1	244:248	PSSSS	SPOP	0.9884	More...
P45983	Mitogen-activated protein kinase 8	DEG_SPOP_SBC_1	390:394	PSSSS	SPOP	0.988	More...
P48751	Anion exchange protein 3	DEG_SPOP_SBC_1	441:445	PSSSS	SPOP	0.9863	More...
P48995	Short transient receptor potential channel 1	DEG_SPOP_SBC_1	23:27	PSSSS	SPOP	0.8905	More...
P55201	Peregrin	DEG_SPOP_SBC_1	950:954	PSSSS	SPOP	0.9386	More...
Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	DEG_SPOP_SBC_1	2117:2121	PSSSS	SPOP	0.9923	More...
Q01538	Myelin transcription factor 1	DEG_SPOP_SBC_1	684:688	PSSSS	SPOP	0.9826	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	358:362	PSSSS	SPOP	0.8546	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	101:105	PSSSS	SPOP	0.9367	More...
Q12837	POU domain, class 4, transcription factor 2	DEG_SPOP_SBC_1	47:51	PSSSS	SPOP	0.9987	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	698:702	PSSSS	SPOP	0.9524	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	1568:1572	PSSSS	SPOP	0.9832	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	146:150	PSSSS	SPOP	0.9966	More...
Q14694	Ubiquitin carboxyl-terminal hydrolase 10	DEG_SPOP_SBC_1	351:355	PSSSS	SPOP	0.9991	More...
Q15070	Mitochondrial inner membrane protein OXA1L	DEG_SPOP_SBC_1	418:422	PSSSS	SPOP	0.9452	More...
Q16585	Beta-sarcoglycan	DEG_SPOP_SBC_1	269:273	PSSSS	SPOP	0.5268	More...
Q17R98	Zinc finger protein 827	DEG_SPOP_SBC_1	966:970	PSSSS	SPOP	0.9308	More...
Q3MII6	TBC1 domain family member 25	DEG_SPOP_SBC_1	560:564	PSSSS	SPOP	0.9952	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1281:1285	PSSSS	SPOP	0.6698	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	939:943	PSSSS	SPOP	0.9287	More...
Q58A45	PAN2-PAN3 deadenylation complex subunit PAN3	DEG_SPOP_SBC_1	16:20	PSSSS	SPOP	0.9796	More...
Q59H18	Serine/threonine-protein kinase TNNI3K	DEG_SPOP_SBC_1	742:746	PSSSS	SPOP	0.9797	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	6363:6367	PSSSS	SPOP	0.9426	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	378:382	PSSSS	SPOP	0.9981	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	446:450	PSSSS	SPOP	0.9956	More...
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_SPOP_SBC_1	612:616	PSSSS	SPOP	0.9966	More...
Q6Q0C0	E3 ubiquitin-protein ligase TRAF7	DEG_SPOP_SBC_1	60:64	PSSSS	SPOP	0.9996	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	251:255	PSSSS	SPOP	0.8853	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2217:2221	PSSSS	SPOP	0.9687	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	53:57	PSSSS	SPOP	0.997	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1070:1074	PSSSS	SPOP	0.8717	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	453:457	PSSSS	SPOP	0.9938	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	265:269	PSSSS	SPOP	0.7755	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	531:535	PSSSS	SPOP	0.864	More...
Q7KZ85	Transcription elongation factor SPT6	DEG_SPOP_SBC_1	1524:1528	PSSSS	SPOP	0.9296	More...
Q7KZ85	Transcription elongation factor SPT6	DEG_SPOP_SBC_1	1653:1657	PSSSS	SPOP	0.989	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	879:883	PSSSS	SPOP	0.889	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1254:1258	PSSSS	SPOP	0.5133	More...
Q8IWT3	Cullin-9	DEG_SPOP_SBC_1	579:583	PSSSS	SPOP	0.9855	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2295:2299	PSSSS	SPOP	0.9846	More...
Q8IX15	Homeobox and leucine zipper protein Homez	DEG_SPOP_SBC_1	283:287	PSSSS	SPOP	0.9911	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	202:206	PSSSS	SPOP	0.9944	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	151:155	PSSSS	SPOP	0.9715	More...
Q8IZD9	Dedicator of cytokinesis protein 3	DEG_SPOP_SBC_1	1740:1744	PSSSS	SPOP	0.9951	More...
Q8N1F7	Nuclear pore complex protein Nup93	DEG_SPOP_SBC_1	768:772	PSSSS	SPOP	0.7728	More...
Q8N5G2	Macoilin	DEG_SPOP_SBC_1	344:348	PSSSS	SPOP	0.9634	More...
Q8NE35	Cytoplasmic polyadenylation element-binding protein 3	DEG_SPOP_SBC_1	220:224	PSSSS	SPOP	0.8709	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	24:28	PSSSS	SPOP	0.9971	More...
Q8NI27	THO complex subunit 2	DEG_SPOP_SBC_1	1208:1212	PSSSS	SPOP	0.9583	More...
Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	DEG_SPOP_SBC_1	851:855	PSSSS	SPOP	0.9525	More...
Q8WUI4	Histone deacetylase 7	DEG_SPOP_SBC_1	199:203	PSSSS	SPOP	0.9441	More...
Q8WX93	Palladin	DEG_SPOP_SBC_1	756:760	PSSSS	SPOP	0.999	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	301:305	PSSSS	SPOP	0.6405	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	556:560	PSSSS	SPOP	0.984	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1270:1274	PSSSS	SPOP	0.9193	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	3702:3706	PSSSS	SPOP	0.941	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	214:218	PSSSS	SPOP	0.7612	More...
Q9BWQ8	Protein lifeguard 2	DEG_SPOP_SBC_1	70:74	PSSSS	SPOP	0.948	More...
Q9BYZ6	Rho-related BTB domain-containing protein 2	DEG_SPOP_SBC_1	720:724	PSSSS	SPOP	0.7707	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1201:1205	PSSSS	SPOP	0.9775	More...
Q9H0H5	Rac GTPase-activating protein 1	DEG_SPOP_SBC_1	589:593	PSSSS	SPOP	0.9995	More...
Q9H3Q1	Cdc42 effector protein 4	DEG_SPOP_SBC_1	69:73	PSSSS	SPOP	0.9451	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	722:726	PSSSS	SPOP	0.9704	More...
Q9H6B4	CXADR-like membrane protein	DEG_SPOP_SBC_1	287:291	PSSSS	SPOP	0.9262	More...
Q9H7D7	WD repeat-containing protein 26	DEG_SPOP_SBC_1	44:48	PSSSS	SPOP	0.9923	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	201:205	PSSSS	SPOP	0.8985	More...
Q9H7Z3	Nuclear exosome regulator NRDE2	DEG_SPOP_SBC_1	104:108	PSSSS	SPOP	0.6574	More...
Q9HCG8	Pre-mRNA-splicing factor CWC22 homolog	DEG_SPOP_SBC_1	668:672	PSSSS	SPOP	0.9061	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2080:2084	PSSSS	SPOP	0.9952	More...
Q9NP79	Vacuolar protein sorting-associated protein VTA1 homolog	DEG_SPOP_SBC_1	193:197	PSSSS	SPOP	0.9408	More...
Q9NQ75	Cas scaffolding protein family member 4	DEG_SPOP_SBC_1	273:277	PSSSS	SPOP	0.999	More...
Q9NRC6	Spectrin beta chain, non-erythrocytic 5	DEG_SPOP_SBC_1	3553:3557	PSSSS	SPOP	0.9237	More...
Q9NRL3	Striatin-4	DEG_SPOP_SBC_1	573:577	PSSSS	SPOP	0.8479	More...
Q9NVW2	E3 ubiquitin-protein ligase RLIM	DEG_SPOP_SBC_1	477:481	PSSSS	SPOP	0.9976	More...
Q9P0U3	Sentrin-specific protease 1	DEG_SPOP_SBC_1	103:107	PSSSS	SPOP	0.9571	More...
Q9UDT6	CAP-Gly domain-containing linker protein 2	DEG_SPOP_SBC_1	315:319	PSSSS	SPOP	0.9467	More...
Q9UHF7	Zinc finger transcription factor Trps1	DEG_SPOP_SBC_1	67:71	PSSSS	SPOP	0.997	More...
Q9UJ14	Glutathione hydrolase 7	DEG_SPOP_SBC_1	71:75	PSSSS	SPOP	0.9905	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	687:691	PSSSS	SPOP	0.7908	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	863:867	PSSSS	SPOP	0.9942	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	211:215	PSSSS	SPOP	0.9945	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	75:79	PSSSS	SPOP	0.9839	More...
Q9Y388	RNA-binding motif protein, X-linked 2	DEG_SPOP_SBC_1	184:188	PSSSS	SPOP	0.9419	More...
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_SPOP_SBC_1	852:856	PSSSS	SPOP	0.945	More...
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_SPOP_SBC_1	876:880	PSSSS	SPOP	0.9112	More...
Q9Y4X0	AMME syndrome candidate gene 1 protein	DEG_SPOP_SBC_1	108:112	PSSSS	SPOP	0.7876	More...
Q9Y6F6	Inositol 1,4,5-triphosphate receptor associated 1	DEG_SPOP_SBC_1	706:710	PSSSS	SPOP	0.7952	More...
Q9Y6N7	Roundabout homolog 1	DEG_SPOP_SBC_1	1601:1605	PSSSS	SPOP	0.9801	More...
A7MBM2	Protein dispatched homolog 2	DEG_SPOP_SBC_1	66:70	PSSSS	SPOP	0.9819	More...
P43363	Melanoma-associated antigen 10	DEG_SPOP_SBC_1	53:57	PSSSS	SPOP	0.9954	More...
Q2MJR0	Sprouty-related, EVH1 domain-containing protein 3	DEG_SPOP_SBC_1	120:124	PSSSS	SPOP	0.9463	More...
Q4G0A6	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4	DEG_SPOP_SBC_1	234:238	PSSSS	SPOP	0.9862	More...
Q6PJQ5	Forkhead box protein R2	DEG_SPOP_SBC_1	132:136	PSSSS	SPOP	0.9182	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	635:639	PSSSS	SPOP	0.965	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_SPOP_SBC_1	999:1003	PSSSS	SPOP	0.7913	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	720:724	PSSSS	SPOP	0.9863	More...
Q96LD1	Zeta-sarcoglycan	DEG_SPOP_SBC_1	258:262	PSSSS	SPOP	0.6136	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	2191:2195	PSSSS	SPOP	0.9783	More...
Q9NR64	Kelch-like protein 1	DEG_SPOP_SBC_1	72:76	PSSSS	SPOP	0.9967	More...
Q9NR64	Kelch-like protein 1	DEG_SPOP_SBC_1	82:86	PSSSS	SPOP	0.9951	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	350:354	PSSSS	SPOP	0.9977	More...
A2CJ06	Dystrotelin	DEG_SPOP_SBC_1	388:392	PSSSS	SPOP	0.9314	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	239:243	PSSSS	SPOP	0.9332	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1461:1465	PSSSS	SPOP	0.9413	More...
Q5TF21	Protein SOGA3	DEG_SPOP_SBC_1	218:222	PSSSS	SPOP	0.8918	More...
Q5VXU3	Cysteine-rich hydrophobic domain-containing protein 1	DEG_SPOP_SBC_1	32:36	PSSSS	SPOP	0.8518	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1089:1093	PSSSS	SPOP	0.9912	More...
Q8IXS8	Protein FAM126B	DEG_SPOP_SBC_1	366:370	PSSSS	SPOP	0.9237	More...
Q96C57	Protein CUSTOS	DEG_SPOP_SBC_1	147:151	PSSSS	SPOP	0.9565	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	142:146	PSSSS	SPOP	0.7478	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	25:29	PSSSS	SPOP	0.6341	More...
A8MXT2	Melanoma-associated antigen B17	DEG_SPOP_SBC_1	39:43	PSSSS	SPOP	0.9755	More...
O95177	Uncharacterized protein GAS8-AS1	DEG_SPOP_SBC_1	113:117	PSSSS	SPOP	0.8372	More...
Q5VZ18	SH2 domain-containing adapter protein E	DEG_SPOP_SBC_1	162:166	PSSSS	SPOP	0.9955	More...
Q6P2S7	Putative tetratricopeptide repeat protein 41	DEG_SPOP_SBC_1	201:205	PSSSS	SPOP	0.5805	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	56:60	PSSSS	SPOP	0.8763	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	83:87	PSSSS	SPOP	0.7647	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	92:96	PSSSS	SPOP	0.8932	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	118:122	PSSSS	SPOP	0.8649	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	129:133	PSSSS	SPOP	0.8649	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	136:140	PSSSS	SPOP	0.8566	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	147:151	PSSSS	SPOP	0.8676	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	154:158	PSSSS	SPOP	0.8727	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	168:172	PSSSS	SPOP	0.7751	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	194:198	PSSSS	SPOP	0.6915	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	208:212	PSSSS	SPOP	0.7	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	223:227	PSSSS	SPOP	0.7624	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	228:232	PSSSS	SPOP	0.742	More...
Q9H693	Uncharacterized protein C16orf95	DEG_SPOP_SBC_1	133:137	PSSSS	SPOP	0.6485	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSSS

Degron related mutations and impact score

Drug responses associated with TNKS mutations

All proteins holding degron of PSSSS