DegronMD - Q59H18(TNNI3K)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L756M	TCGA-AP-A0LM	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0556
p.R742W	TCGA-E6-A1LX	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.8634
p.I745S	TCGA-G7-6789	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7341
p.A747T	TCGA-UZ-A9PK	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.T741S	TCGA-VQ-A8PB	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.Y743H	TCGA-VQ-A8PT	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7229
p.R752W	DO7977	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.R752W	DO234391	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.R752W	SIDM00596	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.R752W	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.R752W	HEC-1	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.C748S	DO222733	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2778
p.S733P	DO222884	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0833
p.C748Y	DO22237	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2778
p.L432F	DO229024	LICA	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation rewiring degron network	0.3056
p.G423V	DO229026	LICA	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation altering degron motif	0.6421
p.V426L	DO229035	LICA	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation altering degron motif	0.5654
p.S736C	DO23048	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.K440I	DO52264	LIHC	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation substituting flanking lysine	0.1944
p.S737N	DO52163	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1944
p.K434M	DO45233	LIRI	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation substituting flanking lysine	0.3611
p.V750L	DO51193	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2222
p.V750L	DO230961	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2222
p.C413S	DO45492	LUSC	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation rewiring degron network	0.0833
p.G753R	DO220877	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.S427Y	DO232761	PBCA	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation altering degron motif	0.712
p.S739C	DO36969	READ	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.25
p.G420E	DO229453	SKCA	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation rewiring degron network	0.2778
p.P755S	DO37819	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0833
p.P755L	DO37819	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0833
p.P742S	DO37409	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.6752
p.G754E	DO47453	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1111
p.S734N	DO48665	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1111
p.S424F	DO38123	SKCM	ICGC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation altering degron motif	0.9093
p.S734R	DO38875	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1111
p.S734R	DO38491	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1111
p.P742L	DO42280	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7582
p.D747H	SIDM01120	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.D747H	ACH-002174	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.D747H	NCI-H720	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.G738A	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2222
p.G738A	ACH-000563	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2222
p.G738A	EBC-1	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2222
p.K440Q	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation substituting flanking lysine	0.1944
p.K440Q	NCI-H647	lung	COSMIC	DGSYVSVPSP	DEG_COP1_1	422:431	Mutation substituting flanking lysine	0.1944
p.S744F	SIDM00240	Cervical Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7982
p.S744F	ACH-002180	Cervical Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7982
p.S744F	OMC-1	cervix	COSMIC	PSSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNNI3K

UniProt ID: Q59H18

Entrez ID: 100526835

Protein name: Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNNI3K in