DegronMD

Uniprot ID: Q59H18

Source protein: Serine/threonine-protein kinase TNNI3K

Source gene: TNNI3K

Class: DEG_COP1_1

Location: 422:431

E3 ligase: COP1

DEGRON score: 0.94

ASA_SCORE: 50.12

COIL: 0.612

CONS_SCORE: 0.3923

DSS_SCORE: 0.4817

HELIX: 0.1414

FCONS_SCORE: 1.0222

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L432F	DO229024	LICA	ICGC	DGSYVSVPSP	DEG_COP1_1	0.3056
p.G423V	DO229026	LICA	ICGC	DGSYVSVPSP	DEG_COP1_1	0.6421
p.V426L	DO229035	LICA	ICGC	DGSYVSVPSP	DEG_COP1_1	0.5654
p.K440I	DO52264	LIHC	ICGC	DGSYVSVPSP	DEG_COP1_1	0.1944
p.K434M	DO45233	LIRI	ICGC	DGSYVSVPSP	DEG_COP1_1	0.3611
p.C413S	DO45492	LUSC	ICGC	DGSYVSVPSP	DEG_COP1_1	0.0833
p.S427Y	DO232761	PBCA	ICGC	DGSYVSVPSP	DEG_COP1_1	0.712
p.G420E	DO229453	SKCA	ICGC	DGSYVSVPSP	DEG_COP1_1	0.2778
p.S424F	DO38123	SKCM	ICGC	DGSYVSVPSP	DEG_COP1_1	0.9093
p.K440Q	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	DGSYVSVPSP	DEG_COP1_1	0.1944
p.K440Q	NCI-H647	lung	COSMIC	DGSYVSVPSP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q59H18	Serine/threonine-protein kinase TNNI3K	DEG_COP1_1	422:431	DGSYVSVPSP	COP1	0.94	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons