DegronMD - Q9H7Z3(NRDE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S108R	TCGA-17-Z056	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.7427
p.D115N	TCGA-19-5956	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1389
p.D115N	TCGA-AA-A010	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1389
p.D115N	TCGA-AZ-4315	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1389
p.D115N	DO8842	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1389
p.D115N	DO13863	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1389
p.Q622R	TCGA-AA-3664	COAD	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.25
p.Q622R	DO7831	COAD	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.25
p.S106G	TCGA-AX-A0J1	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.6993
p.S106G	DO41199	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.6993
p.E609D	TCGA-AX-A1CE	UCEC	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.2222
p.E609D	DO42280	UCEC	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.2222
p.D113N	TCGA-AX-A2HC	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1944
p.D113N	TCGA-E2-A1L7	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1944
p.D113N	DO1937	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1944
p.D113N	DO41572	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1944
p.Q614H	TCGA-DF-A2KU	UCEC	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation altering degron motif	0.647
p.Q614H	DO223286	UCEC	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation altering degron motif	0.647
p.D618V	TCGA-ZP-A9CY	LIHC	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation altering degron motif	0.6674
p.D618V	DO52329	LIHC	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation altering degron motif	0.6674
p.I625V	DO228208	LICA	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1667
p.D113E	DO229031	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1944
p.S116F	DO222638	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.1111
p.P611L	DO222843	MELA	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.2778
p.E605K	DO232761	PBCA	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1111
p.H95Y	DO37782	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0833
p.G103A	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.3056
p.G103A	ACH-000161	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.3056
p.D607H	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1667
p.D607H	ACH-000605	Esophageal Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1667
p.D607H	TE-6	oesophagus	COSMIC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1667
p.S105P	SIDM01045	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.5641
p.S105P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.5641
p.S105P	EN	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.5641
p.E612K	SIDM00841	Colorectal Carcinoma	GDSC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.3056
p.E612K	ACH-000651	Colon/Colorectal Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.3056
p.E612K	ACH-000842	Colon/Colorectal Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.3056
p.E612K	SW620	large intestine	COSMIC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.3056
p.C608F	SIDM00382	Glioblastoma	GDSC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1944
p.C608F	ACH-000609	Brain Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1944
p.C608F	SF126	central nervous system	COSMIC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	613:619	Mutation rewiring degron network	0.1944

Kaplan plot for NRDE2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRDE2

UniProt ID: Q9H7Z3

Entrez ID: 55051

Protein name: Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRDE2 in