DegronMD

Uniprot ID: Q9H7Z3

Source protein: Nuclear exosome regulator NRDE2

Source gene: NRDE2

Class: LIG_APCC_ABBAyCdc20_2

Location: 613:619

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6774

ASA_SCORE: 49.2429

COIL: 0.3087

CONS_SCORE: 0.6088

DSS_SCORE: 0.3337

HELIX: 0.4997

FCONS_SCORE: 1.4103

RIG_SCORE: 0.8396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q622R	TCGA-AA-3664	COAD	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q622R	DO7831	COAD	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.25
p.E609D	TCGA-AX-A1CE	UCEC	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E609D	DO42280	UCEC	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q614H	TCGA-DF-A2KU	UCEC	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.647
p.Q614H	DO223286	UCEC	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.647
p.D618V	TCGA-ZP-A9CY	LIHC	TCGA	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.6674
p.D618V	DO52329	LIHC	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.6674
p.I625V	DO228208	LICA	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P611L	DO222843	MELA	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E605K	DO232761	PBCA	ICGC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D607H	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D607H	ACH-000605	Esophageal Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D607H	TE-6	oesophagus	COSMIC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E612K	SIDM00841	Colorectal Carcinoma	GDSC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E612K	ACH-000651	Colon/Colorectal Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E612K	ACH-000842	Colon/Colorectal Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E612K	SW620	large_intestine	COSMIC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.C608F	SIDM00382	Glioblastoma	GDSC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.C608F	ACH-000609	Brain Cancer	CCLE	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.C608F	SF126	central_nervous_system	COSMIC	RQVLFDD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7Z3	Nuclear exosome regulator NRDE2	LIG_APCC_ABBAyCdc20_2	613:619	RQVLFDD	APC,CDC20,FZR1	0.6774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons