DegronMD - Q9P206(KIAA1522)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S628F	TCGA-52-7810	LUSC	TCGA	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.0833
p.A388T	TCGA-AD-6889	COAD	TCGA	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.3056
p.R379H	TCGA-AJ-A3EK	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	383:387	Mutation blocking phosphorylation signal	0.6667
p.T349N	TCGA-BD-A3ER	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.3056
p.P672Q	TCGA-BQ-7045	KIRP	TCGA	PPSY	ITCH	675:678	Mutation rewiring degron network	0.25
p.G647W	TCGA-D3-A2JC	SKCM	TCGA	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.3056
p.G647W	TCGA-D3-A2JC	SKCM	TCGA	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.1111
p.G647W	TCGA-D3-A2JC	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1667
p.A683S	TCGA-DU-6392	LGG	TCGA	PPSY	ITCH	675:678	Mutation rewiring degron network	0.1944
p.R645C	TCGA-DU-7010	LGG	TCGA	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.25
p.R645C	TCGA-DU-7010	LGG	TCGA	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.0556
p.R645C	TCGA-DU-7010	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.R375H	TCGA-E6-A2P9	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.1111
p.S671F	TCGA-EE-A3J7	SKCM	TCGA	PPSY	ITCH	675:678	Mutation rewiring degron network	0.2222
p.S352L	TCGA-FD-A62O	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.8778
p.S675C	TCGA-S5-A6DX	BLCA	TCGA	PPSY	ITCH	675:678	Mutation altering degron motif	0.7541
p.R391H	TCGA-S9-A7R1	LGG	TCGA	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.2222
p.H663Y	TCGA-SY-A9G5	BLCA	TCGA	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.0833
p.H663Y	TCGA-SY-A9G5	BLCA	TCGA	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.25
p.S639F	DO51906	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7982
p.S379F	DO51906	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation blocking phosphorylation signal	0.6667
p.Q646K	DO51903	BLCA	ICGC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.2778
p.Q646K	DO51903	BLCA	ICGC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.0833
p.Q646K	DO51903	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1944
p.P756L	DO49759	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.3056
p.S353C	DO2966	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.8652
p.S661F	DO219589	BRCA	ICGC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.1389
p.S661F	DO219589	BRCA	ICGC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.3056
p.S375F	DO49902	CESC	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.1111
p.P657Q	DO227987	COCA	ICGC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation altering degron motif	0.7035
p.A630T	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1389
p.A630T	DO229003	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1389
p.A630T	DO229480	LAML	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1389
p.A758T	DO233088	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation altering degron motif	0.6028
p.V340I	DO233245	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.A643T	DO13863	GBM	ICGC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.1944
p.A643T	DO13863	GBM	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2778
p.S759L	DO15294	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation altering degron motif	0.7667
p.V638F	DO229018	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.5957
p.V340F	DO229028	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.S389I	DO229038	LICA	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.2778
p.L766F	DO229045	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.1944
p.P343L	DO229050	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.A758S	DO229008	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation altering degron motif	0.6477
p.W357R	DO44978	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.25
p.S374F	DO22905	LIHC	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0833
p.L752V	DO229292	LMS	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.1944
p.P396T	DO23740	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0833
p.P383L	DO51193	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.7582
p.P649S	DO26444	LUSC	ICGC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation altering degron motif	0.5641
p.S747L	DO27074	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.0556
p.S362F	DO222599	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.S362F	DO37835	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.S362F	DO37425	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.S673F	DO37667	SKCM	ICGC	PPSY	ITCH	675:678	Mutation blocking phosphorylation signal	0.7222
p.Q769H	DO37511	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.1111
p.T685A	DO37409	SKCM	ICGC	PPSY	ITCH	675:678	Mutation blocking phosphorylation signal	0.5833
p.T685I	DO37409	SKCM	ICGC	PPSY	ITCH	675:678	Mutation blocking phosphorylation signal	0.5833
p.P756Q	DO47386	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.3056
p.P383Q	DO229275	THCA	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.7035
p.R346H	DO41871	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2222
p.E660V	DO41235	UCEC	ICGC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation altering degron motif	0.7693
p.S391N	DO41361	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.2222
p.R348C	DO41386	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2778
p.H357R	SIDM00960	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.25
p.H357R	CL-40	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.25
p.R645H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.25
p.R645H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.0556
p.R645H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.R645H	SIDM00282	Colorectal Carcinoma	GDSC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.25
p.R645H	SIDM00282	Colorectal Carcinoma	GDSC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.0556
p.R645H	SIDM00282	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.R645H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.25
p.R645H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.0556
p.R645H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.R645H	CW-2	large intestine	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.25
p.R645H	CW-2	large intestine	COSMIC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.0556
p.R645H	CW-2	large intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.D644N	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.2222
p.D644N	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.25
p.D644N	BC-3	haematopoietic and lymphoid tissue	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.2222
p.D644N	BC-3	haematopoietic and lymphoid tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.25
p.P674L	SIDM00842	Colorectal Carcinoma	GDSC	PPSY	ITCH	675:678	Mutation rewiring degron network	0.3056
p.P674L	COLO-320-HSR	large intestine	COSMIC	PPSY	ITCH	675:678	Mutation rewiring degron network	0.3056
p.L377P	SIDM00537	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.1667
p.L377P	GP5d	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.1667
p.P361L	SIDM01018	Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.P361L	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.K686R	ACH-000070	Leukemia	CCLE	PPSY	ITCH	675:678	Mutation substituting flanking lysine	0.2222
p.K686R	697	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	675:678	Mutation substituting flanking lysine	0.2222
p.P675T	ACH-000120	Neuroblastoma	CCLE	PPSY	ITCH	675:678	Mutation altering degron motif	0.7031
p.S647F	ACH-000607	Rhabdoid	CCLE	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.3056
p.S647F	ACH-000607	Rhabdoid	CCLE	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.1111
p.S647F	ACH-000607	Rhabdoid	CCLE	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1667
p.S647F	KYM-1	soft tissue	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	648:654	Mutation rewiring degron network	0.3056
p.S647F	KYM-1	soft tissue	COSMIC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.1111
p.S647F	KYM-1	soft tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1667
p.P345H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1944
p.G748D	ACH-000995	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.0833
p.G748D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation rewiring degron network	0.0833
p.P672H	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	675:678	Mutation rewiring degron network	0.25
p.P672H	HCT-15	large intestine	COSMIC	PPSY	ITCH	675:678	Mutation rewiring degron network	0.25
p.Q668L	ACH-002123	Lung Cancer	CCLE	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.1111
p.Q668L	ACH-002123	Lung Cancer	CCLE	PPSY	ITCH	675:678	Mutation rewiring degron network	0.1389
p.Q668L	H2369	pleura	COSMIC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation rewiring degron network	0.1111
p.Q668L	H2369	pleura	COSMIC	PPSY	ITCH	675:678	Mutation rewiring degron network	0.1389
p.G759D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	757:761	Mutation altering degron motif	0.7198
p.T387M	NCI-H211	lung	COSMIC	PESST	DEG_SPOP_SBC_1	383:387	Mutation altering degron motif	0.7423
p.P683H	HCT-15	large intestine	COSMIC	PPSY	ITCH	675:678	Mutation rewiring degron network	0.1944
p.S658F	KYM-1	soft tissue	COSMIC	LTPLQE	DEG_SCF_FBW7_2	655:660	Mutation altering degron motif	0.7982
p.Q679L	H2369	pleura	COSMIC	PPSY	ITCH	675:678	Mutation rewiring degron network	0.3056
p.N390H	DU-145	prostate	COSMIC	PESST	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1522

UniProt ID: Q9P206

Entrez ID: 57648

Protein name: Uncharacterized protein KIAA1522

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1522 in