DegronMD

Uniprot ID: Q9P206

Source protein: Uncharacterized protein KIAA1522

Source gene: KIAA1522

Class: DEG_SPOP_SBC_1

Location: 350:354

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 75.32

COIL: 0.9488

CONS_SCORE: 0.4969

DSS_SCORE: 0.6957

HELIX: 0.0352

FCONS_SCORE: 0.9863

RIG_SCORE: 0.4927

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S352L	TCGA-FD-A62O	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	0.8778
p.S353C	DO2966	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.8652
p.T349N	TCGA-BD-A3ER	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.3056
p.R348C	DO41386	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2778
p.W357R	DO44978	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.25
p.H357R	SIDM00960	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.25
p.H357R	CL-40	large_intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.25
p.R346H	DO41871	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2222
p.P345H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.1944
p.P343L	DO229050	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.P361L	SIDM01018	Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.P361L	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.S362F	DO222599	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1111
p.S362F	DO37835	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1111
p.S362F	DO37425	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1111
p.V340I	DO233245	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.0556
p.V340F	DO229028	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 17 of 17 entries

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Drug responses associated with KIAA1522 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1276:1280	PSSSS	SPOP	0.9293	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	698:702	PSSSS	SPOP	0.9524	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	832:836	PSSSS	SPOP	0.995	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1144:1148	PSSSS	SPOP	0.9971	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1872:1876	PSSSS	SPOP	0.9707	More...
Q9Y4X0	AMME syndrome candidate gene 1 protein	DEG_SPOP_SBC_1	108:112	PSSSS	SPOP	0.7876	More...
P48751	Anion exchange protein 3	DEG_SPOP_SBC_1	441:445	PSSSS	SPOP	0.9863	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2295:2299	PSSSS	SPOP	0.9846	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	863:867	PSSSS	SPOP	0.9942	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_SPOP_SBC_1	1242:1246	PSSSS	SPOP	0.9873	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1281:1285	PSSSS	SPOP	0.6698	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	214:218	PSSSS	SPOP	0.7612	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	841:845	PSSSS	SPOP	0.9975	More...
Q16585	Beta-sarcoglycan	DEG_SPOP_SBC_1	269:273	PSSSS	SPOP	0.5268	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	290:294	PSSSS	SPOP	0.9979	More...
Q9UDT6	CAP-Gly domain-containing linker protein 2	DEG_SPOP_SBC_1	315:319	PSSSS	SPOP	0.9467	More...
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SPOP_SBC_1	272:276	PSSSS	SPOP	0.9973	More...
Q9NQ75	Cas scaffolding protein family member 4	DEG_SPOP_SBC_1	273:277	PSSSS	SPOP	0.999	More...
Q9H3Q1	Cdc42 effector protein 4	DEG_SPOP_SBC_1	69:73	PSSSS	SPOP	0.9451	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	531:535	PSSSS	SPOP	0.864	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2080:2084	PSSSS	SPOP	0.9952	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	151:155	PSSSS	SPOP	0.9715	More...
P38432	Coilin	DEG_SPOP_SBC_1	244:248	PSSSS	SPOP	0.9884	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	358:362	PSSSS	SPOP	0.8546	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	301:305	PSSSS	SPOP	0.6405	More...

Showing 1 to 25 of 159 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSSS

Degron related mutations and impact score

Drug responses associated with KIAA1522 mutations

All proteins holding degron of PSSSS