DegronMD - Q8IWZ3(ANKHD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1511A	TCGA-06-0171	GBM	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7139
p.T1511A	DO11382	GBM	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7139
p.L46R	TCGA-19-0957	GBM	TCGA	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation altering degron motif	0.8428
p.L46R	DO11028	GBM	ICGC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation altering degron motif	0.8428
p.S2306C	TCGA-91-8499	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	2295:2299	Mutation rewiring degron network	0.1389
p.S2306C	DO45349	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	2295:2299	Mutation rewiring degron network	0.1389
p.Q2082R	TCGA-A5-A0VQ	UCEC	TCGA	PTPTSS	DEG_SCF_FBW7_1	2070:2075	Mutation rewiring degron network	0.1389
p.V19G	TCGA-AA-3947	COAD	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.0833
p.V19G	DO8192	COAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.0833
p.H1789N	TCGA-AA-3984	COAD	TCGA	IRTPAST	DEG_SCF_FBW7_1	1779:1785	Mutation rewiring degron network	0.2222
p.P1506R	TCGA-BR-8591	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.25
p.P1506R	DO47973	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.25
p.P1503S	TCGA-D6-6516	HNSC	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1667
p.P1503S	TCGA-DK-A1AC	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1667
p.P1503S	DO514	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1667
p.P1503S	DO15623	HNSC	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1667
p.P1507S	TCGA-DK-A6B1	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.P1507S	DO48534	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2778
p.S2007N	TCGA-E6-A1LX	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	2005:2009	Mutation altering degron motif	0.7069
p.T1510I	TCGA-EE-A2MS	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5966
p.T1510I	DO37567	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.5966
p.E1771D	TCGA-EO-A22U	UCEC	TCGA	IRTPAST	DEG_SCF_FBW7_1	1779:1785	Mutation rewiring degron network	0.1111
p.P1043S	TCGA-ER-A193	SKCM	TCGA	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.3056
p.P1043S	DO47368	SKCM	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.3056
p.T1514M	TCGA-EY-A549	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.3056
p.T1514M	DO48174	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.3056
p.P1040S	TCGA-FW-A3R5	SKCM	TCGA	PPVY	ITCH	1039:1042	Mutation altering degron motif	0.6752
p.P1040S	DO37406	SKCM	ICGC	PPVY	ITCH	1039:1042	Mutation altering degron motif	0.6752
p.S2068N	TCGA-G4-6588	COAD	TCGA	PTPTSS	DEG_SCF_FBW7_1	2070:2075	Mutation rewiring degron network	0.2778
p.P1043L	TCGA-GN-A4U8	SKCM	TCGA	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.3056
p.P1043L	DO47320	SKCM	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.3056
p.S1035P	TCGA-VQ-A8PT	STAD	TCGA	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.2222
p.S1035P	DO51776	STAD	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.2222
p.H14D	DO516	BLCA	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.2222
p.S6C	DO516	BLCA	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation altering degron motif	0.8652
p.S1521C	DO234426	ESAD	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1111
p.P2309A	DO233290	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	2295:2299	Mutation rewiring degron network	0.0556
p.V35M	DO44525	KIRP	ICGC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.0833
p.Q1500L	DO228218	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.0833
p.D1046H	DO232029	LICA	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.2222
p.V1045F	DO229038	LICA	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.25
p.A1509T	DO50970	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation altering degron motif	0.7139
p.S1037L	DO231649	LINC	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.2778
p.L39V	DO231672	LINC	ICGC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1944
p.S5G	DO45061	LINC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation altering degron motif	0.8104
p.S5N	DO45061	LINC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation altering degron motif	0.818
p.H1789Y	DO45151	LIRI	ICGC	IRTPAST	DEG_SCF_FBW7_1	1779:1785	Mutation rewiring degron network	0.2222
p.P34L	DO26280	LUAD	ICGC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.0556
p.E1501D	DO232761	PBCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.1111
p.G2292C	DO232224	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	2295:2299	Mutation rewiring degron network	0.25
p.Y8N	DO220239	SARC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	4:10	Mutation altering degron motif	0.817
p.P54Q	DO37782	SKCM	ICGC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation blocking phosphorylation signal	0.6389
p.D1046G	DO38404	STAD	ICGC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.2222
p.L49F	DO41331	UCEC	ICGC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation altering degron motif	0.6981
p.E1505D	ACH-000146	Leukemia	CCLE	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2222
p.E1505D	THP-1	haematopoietic and lymphoid tissue	COSMIC	ATTTT	DEG_SPOP_SBC_1	1509:1513	Mutation rewiring degron network	0.2222
p.Q2016E	ACH-000344	Gastric Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	2005:2009	Mutation rewiring degron network	0.1389
p.V1045I	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.25
p.T1030A	ACH-000973	Bladder Cancer	CCLE	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.0833
p.P2309Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	2295:2299	Mutation rewiring degron network	0.0556
p.S48P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation altering degron motif	0.6752
p.S43N	KP-1N	pancreas	COSMIC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation blocking phosphorylation signal	0.75
p.I1047V	LIM1215	large intestine	COSMIC	PPVY	ITCH	1039:1042	Mutation rewiring degron network	0.1944
p.S1996N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	2005:2009	Mutation rewiring degron network	0.0833
p.I56K	NCI-H1734	lung	COSMIC	VRLFGE	LIG_APCC_ABBA_1	44:49	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKHD1

UniProt ID: Q8IWZ3

Entrez ID: 404734

Protein name: Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKHD1 in