DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPTSS
Uniprot ID:
Q8IWZ3
Source protein:
Ankyrin repeat and KH domain-containing protein 1
Source gene:
ANKHD1
Class:
DEG_SCF_FBW7_1
Location:
2070:2075
E3 ligase:
FBXW7
DEGRON score:
0.9813
ASA_SCORE:
90.1833
COIL:
0.964
CONS_SCORE:
0.3949
DSS_SCORE:
0.8439
HELIX:
0.021
FCONS_SCORE:
1.0587
RIG_SCORE:
0.4881
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q2082R
TCGA-A5-A0VQ
UCEC
TCGA
PTPTSS
DEG_SCF_FBW7_1
0.1389
p.S2068N
TCGA-G4-6588
COAD
TCGA
PTPTSS
DEG_SCF_FBW7_1
0.2778
Drug responses associated with ANKHD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IWZ3
Ankyrin repeat and KH domain-containing protein 1
DEG_SCF_FBW7_1
2070:2075
PTPTSS
FBXW7
0.9813
More...