DegronMD

Uniprot ID: Q8IWZ3

Source protein: Ankyrin repeat and KH domain-containing protein 1

Source gene: ANKHD1

Class: DEG_SPOP_SBC_1

Location: 1509:1513

E3 ligase: SPOP

DEGRON score: 0.9091

ASA_SCORE: 84.1

COIL: 0.8528

CONS_SCORE: 0.4578

DSS_SCORE: 0.6519

HELIX: 0.0584

FCONS_SCORE: 1.0482

RIG_SCORE: 0.7145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1511A	TCGA-06-0171	GBM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.7139
p.T1511A	DO11382	GBM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7139
p.P1506R	TCGA-BR-8591	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.25
p.P1506R	DO47973	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.P1503S	TCGA-D6-6516	HNSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1667
p.P1503S	TCGA-DK-A1AC	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1667
p.P1503S	DO514	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.P1503S	DO15623	HNSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.P1507S	TCGA-DK-A6B1	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2778
p.P1507S	DO48534	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.T1510I	TCGA-EE-A2MS	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.5966
p.T1510I	DO37567	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.5966
p.T1514M	TCGA-EY-A549	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.3056
p.T1514M	DO48174	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.S1521C	DO234426	ESAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.Q1500L	DO228218	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.A1509T	DO50970	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7139
p.E1501D	DO232761	PBCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.E1505D	ACH-000146	Leukemia	CCLE	ATTTT	DEG_SPOP_SBC_1	0.2222
p.E1505D	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with ANKHD1 mutations

All proteins holding degron of ATTTT