DegronMD

Uniprot ID: O94856

Source protein: Neurofascin

Source gene: NFASC

Class: DEG_SPOP_SBC_1

Location: 1079:1083

E3 ligase: SPOP

DEGRON score: 0.901

ASA_SCORE: 55.46

COIL: 0.4416

CONS_SCORE: 0.2951

DSS_SCORE: 0.4245

HELIX: 0.0266

FCONS_SCORE: 1.0274

RIG_SCORE: 0.8286

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1076G	TCGA-2H-A9GQ	ESCA	TCGA	ATTTT	DEG_SPOP_SBC_1	0.25
p.V1089I	TCGA-44-7669	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1667
p.V1089I	DO25262	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.V1089I	SIDM02048	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.T1074K	TCGA-92-8064	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T1074K	DO26957	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T1074M	TCGA-BG-A0M0	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T1074M	DO225404	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T1074M	DO231056	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T1074M	DO40810	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.I1085T	TCGA-BP-4972	KIRC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2778
p.I1085T	DO16194	KIRC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.G1070W	TCGA-D3-A2JL	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0833
p.G1070W	TCGA-ER-A19F	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0833
p.G1070W	DO37679	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.G1070W	DO47278	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.R1076W	TCGA-DM-A1HB	COAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.25
p.A1074T	DO48504	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.A1074T	DO10276	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.A1074T	DO51407	PRAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.I1078M	DO228483	BRCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.I1078M	DO227999	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.I1078M	DO229013	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.I1078M	DO229346	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.I1078M	DO229505	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.I1078M	DO228947	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.V1084I	DO223732	CESC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.V1084I	DO233647	GACA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.V1084I	DO36745	READ	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.A1079T	DO228967	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7139
p.A1079T	DO229056	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7139
p.R1080L	DO228971	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.8428
p.T1076I	DO229054	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.A1093T	DO229253	THCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.Y1078N	DO229242	THCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.Y1073C	SIDM01619	Endometrial Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.Y1073C	ACH-000984	Endometrial/Uterine Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.1667
p.G1071D	OVK-18	ovary	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with NFASC mutations

All proteins holding degron of ATTTT