DegronMD

Uniprot ID: P58401

Source protein: Neurexin-2-beta

Source gene: NRXN2

Class: DEG_SPOP_SBC_1

Location: 327:331

E3 ligase: SPOP

DEGRON score: 0.9847

ASA_SCORE: 90.94

COIL: 0.9114

CONS_SCORE: 0.5974

DSS_SCORE: 0.6657

HELIX: 0.029

FCONS_SCORE: 1.1591

RIG_SCORE: 0.7861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K332N	TCGA-33-4586	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.3056
p.N324K	TCGA-60-2714	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.25
p.R323H	TCGA-AJ-A3OJ	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2222
p.R323H	TCGA-AP-A0LM	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2222
p.N338D	TCGA-B5-A3FA	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1389
p.R319C	TCGA-BR-8591	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1111
p.A334T	TCGA-L5-A4OI	ESCA	TCGA	ATTTT	DEG_SPOP_SBC_1	0.25
p.A335V	DO8634	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.S330P	DO230311	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.6752
p.L336H	DO229053	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.A332V	DO232761	PBCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.L336F	DO50301	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.A335T	DO47849	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.R323C	SIDM01943	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.D335N	SIDM01044	Other Solid Cancers	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.D335N	ACH-000585	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.2222
p.D335N	EPLC-272H	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.N338T	SIDM00878	Breast Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.N338T	ACH-000930	Breast Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.1389
p.N338T	HCC1569	breast	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.H329N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.7423
p.H329N	ACH-000945	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.7423
p.H329N	NCI-H650	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.7423
p.R323L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.R323L	ACH-000951	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.2222
p.R323L	NCI-H2342	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.D335H	ACH-001386	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.2222
p.S336C	BT-474	breast	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with NRXN2 mutations

All proteins holding degron of ATTTT