DegronMD - O94856(NFASC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G155D	TCGA-06-5416	GBM	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1111
p.G155D	DO10880	GBM	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1111
p.Q153K	TCGA-17-Z030	LUAD	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1667
p.R1076G	TCGA-2H-A9GQ	ESCA	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.25
p.Q438H	TCGA-33-4566	LUSC	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.647
p.V1089I	TCGA-44-7669	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.V1089I	DO25262	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.V1089I	SIDM02048	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.T1074K	TCGA-92-8064	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.T1074K	DO26957	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.V151M	TCGA-AA-3713	COAD	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.V151M	DO8400	COAD	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.V151M	DO234389	ESAD	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.R449Q	TCGA-AA-3866	COAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.Q438K	TCGA-AG-3731	READ	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5833
p.T1074M	TCGA-BG-A0M0	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.T1074M	DO225404	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.T1074M	DO231056	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.T1074M	DO40810	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.I1085T	TCGA-BP-4972	KIRC	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.2778
p.I1085T	DO16194	KIRC	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.2778
p.S139Y	TCGA-BQ-7062	KIRP	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.S139Y	TCGA-EY-A1GI	UCEC	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.S139Y	DO20883	KIRP	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.S139Y	DO41211	UCEC	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.2222
p.R449W	TCGA-BR-8382	STAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.R449W	TCGA-CM-5341	COAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.G1070W	TCGA-D3-A2JL	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0833
p.G1070W	TCGA-ER-A19F	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0833
p.G1070W	DO37679	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0833
p.G1070W	DO47278	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0833
p.R1076W	TCGA-DM-A1HB	COAD	TCGA	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.25
p.E145K	TCGA-EE-A29H	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.7022
p.E145K	TCGA-EE-A2MS	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.7022
p.E145K	DO37535	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.7022
p.E145K	DO37567	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.7022
p.G155S	TCGA-EE-A2MJ	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1111
p.G155S	DO38099	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1111
p.L444I	TCGA-EI-6917	READ	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.L444I	TCGA-EO-A22X	UCEC	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.L444I	DO36881	READ	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.L444I	DO43907	UCEC	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.L444I	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.L444I	SIDM01681	Non-Cancerous	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.L444I	ACH-002362	Non-Cancerous	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.R133H	TCGA-EO-A22R	UCEC	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.0556
p.R133H	DO42713	UCEC	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.0556
p.P140S	TCGA-FW-A3R5	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.25
p.P140S	DO37406	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.25
p.P157L	TCGA-FW-A3R5	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.0556
p.P157L	DO37406	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.0556
p.R436Q	TCGA-NH-A50T	COAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.7329
p.R436Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.7329
p.R436Q	ACH-000444	Lung Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.7329
p.R436Q	LU-99A	lung	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.7329
p.P435H	TCGA-NJ-A4YQ	LUAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.6583
p.A1074T	DO48504	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.A1074T	DO10276	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.A1074T	DO51407	PRAD	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1944
p.I1078M	DO228483	BRCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.I1078M	DO227999	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.I1078M	DO229013	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.I1078M	DO229346	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.I1078M	DO229505	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.I1078M	DO228947	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.V1084I	DO223732	CESC	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.V1084I	DO233647	GACA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.V1084I	DO36745	READ	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.R447Q	DO44086	COAD	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R447Q	SIDM00945	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R447Q	ACH-000895	Colon/Colorectal Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R447Q	LU-99A	lung	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R447Q	CL-34	large intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.D438G	DO222860	COCA	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.7198
p.A1079T	DO228967	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation altering degron motif	0.7139
p.A1079T	DO229056	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation altering degron motif	0.7139
p.R1080L	DO228971	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation altering degron motif	0.8428
p.T448M	DO229052	LICA	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1944
p.T1076I	DO229054	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.25
p.D427Y	DO229006	LICA	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1111
p.P429H	DO218944	LUAD	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.S445L	DO231191	LUSC	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation blocking phosphorylation signal	0.7222
p.Q449H	DO26790	LUSC	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.Q449K	DO36463	READ	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1667
p.A1093T	DO229253	THCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0556
p.Y1078N	DO229242	THCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.R447W	SIDM02041	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.V425L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.V425L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.V425L	ACH-000995	Leukemia	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.V425L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.S434A	SIDM00781	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.S434A	SIDM00780	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.S434A	ACH-000967	Colon/Colorectal Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.S434A	ACH-001199	Colon/Colorectal Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.S434A	SNU-C2B	large intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.R436L	SIDM01169	Ovarian Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.8428
p.R436L	ACH-000885	Ovarian Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.8428
p.R436L	TOV-21G	ovary	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.8428
p.R431Q	SIDM00603	Head and Neck Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R431Q	ACH-001543	Head and Neck Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.R431Q	KOSC-2	upper aerodigestive tract	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.Y1073C	SIDM01619	Endometrial Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.Y1073C	ACH-000984	Endometrial/Uterine Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.P143S	ACH-001001	Bone Cancer	CCLE	PKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.5641
p.G1071D	OVK-18	ovary	COSMIC	ATTTT	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1111
p.S445A	SNU-C2B	large intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation blocking phosphorylation signal	0.7222
p.R430Q	LU-99A	lung	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1944
p.R425Q	KOSC-2	upper aerodigestive tract	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.R442Q	KOSC-2	upper aerodigestive tract	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.7329
p.V436L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.6765
p.R447L	TOV-21G	ovary	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.2222
p.A432T	HT-115	large intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25
p.R430L	TOV-21G	ovary	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1944
p.S428A	SNU-C2B	large intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1389
p.R441Q	CL-34	large intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.6218

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFASC

UniProt ID: O94856

Entrez ID: 23114

Protein name: Neurofascin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFASC in