DegronMD

Uniprot ID: O94856

Source protein: Neurofascin

Source gene: NFASC

Class: DEG_APCC_KENBOX_2

Location: 143:147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9786

ASA_SCORE: 97.78

COIL: 0.9198

CONS_SCORE: 0.3276

DSS_SCORE: 0.3741

HELIX: 0.0244

FCONS_SCORE: 0.8655

RIG_SCORE: 0.7374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G155D	TCGA-06-5416	GBM	TCGA	PKENL	DEG_APCC_KENBOX_2	0.1111
p.G155D	DO10880	GBM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.1111
p.Q153K	TCGA-17-Z030	LUAD	TCGA	PKENL	DEG_APCC_KENBOX_2	0.1667
p.V151M	TCGA-AA-3713	COAD	TCGA	PKENL	DEG_APCC_KENBOX_2	0.2222
p.V151M	DO8400	COAD	ICGC	PKENL	DEG_APCC_KENBOX_2	0.2222
p.V151M	DO234389	ESAD	ICGC	PKENL	DEG_APCC_KENBOX_2	0.2222
p.S139Y	TCGA-BQ-7062	KIRP	TCGA	PKENL	DEG_APCC_KENBOX_2	0.2222
p.S139Y	TCGA-EY-A1GI	UCEC	TCGA	PKENL	DEG_APCC_KENBOX_2	0.2222
p.S139Y	DO20883	KIRP	ICGC	PKENL	DEG_APCC_KENBOX_2	0.2222
p.S139Y	DO41211	UCEC	ICGC	PKENL	DEG_APCC_KENBOX_2	0.2222
p.E145K	TCGA-EE-A29H	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	0.7022
p.E145K	TCGA-EE-A2MS	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	0.7022
p.E145K	DO37535	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.7022
p.E145K	DO37567	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.7022
p.G155S	TCGA-EE-A2MJ	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	0.1111
p.G155S	DO38099	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.1111
p.R133H	TCGA-EO-A22R	UCEC	TCGA	PKENL	DEG_APCC_KENBOX_2	0.0556
p.R133H	DO42713	UCEC	ICGC	PKENL	DEG_APCC_KENBOX_2	0.0556
p.P140S	TCGA-FW-A3R5	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	0.25
p.P140S	DO37406	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.25
p.P157L	TCGA-FW-A3R5	SKCM	TCGA	PKENL	DEG_APCC_KENBOX_2	0.0556
p.P157L	DO37406	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.0556
p.P143S	ACH-001001	Bone Cancer	CCLE	PKENL	DEG_APCC_KENBOX_2	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94856	Neurofascin	DEG_APCC_KENBOX_2	143:147	PKENL	APC,CDC20,FZR1	0.9786	More...
Q13127	RE1-silencing transcription factor	DEG_APCC_KENBOX_2	868:872	PKENL	APC,CDC20,FZR1	0.7388	More...
Q99550	M-phase phosphoprotein 9	DEG_APCC_KENBOX_2	837:841	PKENL	APC,CDC20,FZR1	0.9987	More...
Q9BYD2	39S ribosomal protein L9, mitochondrial	DEG_APCC_KENBOX_2	90:94	PKENL	APC,CDC20,FZR1	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons