DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PKENL
Uniprot ID:
Q9BYD2
Source protein:
39S ribosomal protein L9, mitochondrial
Source gene:
MRPL9
Class:
DEG_APCC_KENBOX_2
Location:
90:94
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9892
ASA_SCORE:
80.02
COIL:
0.7222
CONS_SCORE:
0.3909
DSS_SCORE:
0.3545
HELIX:
0.049
FCONS_SCORE:
0.7478
RIG_SCORE:
0.7816
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L82M
TCGA-OR-A5JA
ACC
TCGA
PKENL
DEG_APCC_KENBOX_2
0.1111
p.I97T
SIDM00876
Non-Cancerous
GDSC
PKENL
DEG_APCC_KENBOX_2
0.25
Drug responses associated with MRPL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKENL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94856
Neurofascin
DEG_APCC_KENBOX_2
143:147
PKENL
APC,CDC20,FZR1
0.9786
More...
Q13127
RE1-silencing transcription factor
DEG_APCC_KENBOX_2
868:872
PKENL
APC,CDC20,FZR1
0.7388
More...
Q99550
M-phase phosphoprotein 9
DEG_APCC_KENBOX_2
837:841
PKENL
APC,CDC20,FZR1
0.9987
More...
Q9BYD2
39S ribosomal protein L9, mitochondrial
DEG_APCC_KENBOX_2
90:94
PKENL
APC,CDC20,FZR1
0.9892
More...