DegronMD

Uniprot ID: Q13127

Source protein: RE1-silencing transcription factor

Source gene: REST

Class: DEG_APCC_KENBOX_2

Location: 868:872

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7388

ASA_SCORE: 103.52

COIL: 0.7896

CONS_SCORE: 0.314

DSS_SCORE: 0.7588

HELIX: 0.1892

FCONS_SCORE: 0.7342

RIG_SCORE: 0.6393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N871K	TCGA-DU-6392	LGG	TCGA	PKENL	DEG_APCC_KENBOX_2	0.6918
p.N871K	DO22237	LGG	ICGC	PKENL	DEG_APCC_KENBOX_2	0.6918
p.D859V	DO228080	EOPC	ICGC	PKENL	DEG_APCC_KENBOX_2	0.0833
p.E858A	DO233871	GACA	ICGC	PKENL	DEG_APCC_KENBOX_2	0.0556
p.K881I	DO231786	LINC	ICGC	PKENL	DEG_APCC_KENBOX_2	0.1944
p.L882I	SIDM01574	Plasma Cell Myeloma	GDSC	PKENL	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94856	Neurofascin	DEG_APCC_KENBOX_2	143:147	PKENL	APC,CDC20,FZR1	0.9786	More...
Q13127	RE1-silencing transcription factor	DEG_APCC_KENBOX_2	868:872	PKENL	APC,CDC20,FZR1	0.7388	More...
Q99550	M-phase phosphoprotein 9	DEG_APCC_KENBOX_2	837:841	PKENL	APC,CDC20,FZR1	0.9987	More...
Q9BYD2	39S ribosomal protein L9, mitochondrial	DEG_APCC_KENBOX_2	90:94	PKENL	APC,CDC20,FZR1	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons